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Prediction of risk for pseudoallergic reactions and histamine release in patients undergoing anaesthesia and surgery: A computer-aided model using independence-Bayes

  • Histamine in Pathophysiology and Clinical Studies
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Abstract

A computer-aided model for the prediction of pseudoallergic reactions was developed using prospective data collected from 581 patients in a controlled clinical trial examining pseudoallergic reactions to the plasma substitute Haemaccel (outdated formulation). The multivariate analysis of 22 proposed risk factors was performed using Bayes theorem. This enabled the accurate prediction of 86% of the patients who had a systemic reaction. The clinical use of such system would enable a selection of patients to receive the effective prophylactic measure of pretreatment with H1 plus H2-receptor antagonists.

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Authors and Affiliations

  1. Institute for Theoretical Surgery, Centre for Operative Medicine I, Philipps University Marburg, D-3550, Marburg

    M. Ennis, C. Ohmann, W. Lorenz & R. Zaczyk

  2. Department of Anaesthesiology, Orthopedic Clinic, Heidelberg, FRG

    B. Schöning

Authors
  1. M. Ennis
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  2. C. Ohmann
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  3. W. Lorenz
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  4. R. Zaczyk
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  5. B. Schöning
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Supported by a grant from the Deutsche Forschungsgemeinschaft (Lo 199/14-2).

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Ennis, M., Ohmann, C., Lorenz, W. et al. Prediction of risk for pseudoallergic reactions and histamine release in patients undergoing anaesthesia and surgery: A computer-aided model using independence-Bayes. Agents and Actions 23, 366–369 (1988). https://doi.org/10.1007/BF02142589

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  • DOI: https://doi.org/10.1007/BF02142589

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