Summary
The percentage of DNA-synthesising heart muscle nuclei of white rats (3H-thymidine, autoradiography) decreases rapidly during the first month of life reaching a minimum at the fourth month. From then up to 27 months the number of labelled muscle nuclei remains rather constant. Also in nuclei of connective tissue the3H-thymidine labelling index decreases as a function of the rats age. The number of mitotic figures is always about 10 times lower than labelled nuclei. Mostly in heart muscle cells they occur as collapsed mitoses never leading to cytoplasma division14.
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Klinge, O., Stöcker, E. Die DNS-synthese im rattenherzen als funktion des lebensalters. Autoradiographische untersuchungen mit3H-thymidin. Experientia 24, 167–168 (1968). https://doi.org/10.1007/BF02146965
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DOI: https://doi.org/10.1007/BF02146965