Summary
In vagotomized adult cats with the spinal cord transected at T2, short trains of electrical pulses delivered to the central gray substance of the midbrain and the ventral hippocampus initiated a phase reversal in respiration from expiration to inspiration. A transition from inspiration to expiration, however, was not observed. It is suggested that this phase-switch may be mediated via a reticular formation input into the medulla rather than via the pontine “synchronizing mechanisms”.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Anand, B. K., andS. Dua: Circulatory and respiratory changes induced by electrical stimulation of limbic system (visceral brain). J. Neurophysiol.19, 393–400 (1956).
Batsel, H. L.: Localization of bulbar respiratory center by microelectrode sounding. Exp. Neurol.9, 410–426 (1964).
Bertrand, F., andA. Hugelin: Respiratory synchronizing function of nucleus parabrachialis medialis: Pneumotaxic mechanisms. J. Neurophysiol.34, 189–207 (1971).
Cohen, M. I.: Switching of the respiratory phases and evoked phrenic responses produced by rostral pontine electrical stimulation. J. Physiol. (London)217, 133–158 (1971).
Danilewsky, B.: Experimentelle Beiträge zur Physiologic des Gehirns. Pflugers Arch. ges. Physiol.11, 128–138 (1875).
Duffin, J., andC. H. Hockman: Limbic forebrain and midbrain modulation and phase-switching of expiratory neurons. Brain Research39, 235–239 (1972).
Hockman, C. H., J. Talesnik, andK. E. Livingston: Central nervous system modulation of barocepter reflexes. Am. J. Physiol.217, 1681–1689 (1969).
Hugelin, A., andM. I. Cohen: The reticular activating system and respiratory regulation in the cat. Ann. N.Y. Acad. Sci.109, 586–603 (1963).
Kaada, B. R.: Somato-motor, autonomic and electrocorticographic responses to electrical stimulation of rhinencephalic and other structures in primates, cats and dogs. Acta Physiol. Scand.24, Suppl. 83, 1–285 (1951).
Marshall, W. H.: An application of the frozen sectioning technic for cutting serial sections through the brain. Stain. Technol.15, 133–137 (1940).
Merrill, E. G.: The lateral respiratory neurons of the medulla: their associations with nucleus ambiguous, nucleus retroambigualis, the spinal accessory nucleus and the spinal cord. Brain Research24, 11–28 (1970).
Nauta, W. J. H.: Hippocampal projections and related neural pathways to the midbrain in the cat. Brain81, 319–341 (1958).
Nelson, J. R.: Single unit activity in medullary respiratory center of cat. J. Neurophysiol.22, 590–598 (1959).
Salmoiraghi, G. C., andB. D. Burns: Localization and patterns of discharge of respiratory neurones in the brainstem of cat. J. Neurophysiol.23, 2–13 (1960).
Snider, R. S., andW. T. Niemer: A Stereotaxic Atlas of the Cat Brain Chicago: Univ. Chicago Press. 1961.
Author information
Authors and Affiliations
Additional information
With 5 Figures
This investigation was supported by grants from the Addiction Research Foundation of Ontario, and the Medical Research Council of Canada. — A preliminary report of portions of this work was presented at the 7th Annual Winter Conference on Brain Research at Steamboat Springs, Colorado in January, 1974.
Rights and permissions
About this article
Cite this article
Hockman, C.H., Duffin, J., Rupert, A.H. et al. Phase-switching of respiration induced by central gray and hippocampal stimulation in the cat. J. Neural Transmission 35, 327–335 (1974). https://doi.org/10.1007/BF02205229
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02205229