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A multivariate data reduction system

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Abstract

The problem of predictive diagnosis based on laboratory data is approached from a mathematical standpoint. A descriptive system is introduced which examines the current information about a clinical problem and identifies best predictors of the problem. Algorithms are described for the assessment of current diagnostic ability, the evaluation of new laboratory tests, and the identification of patients to study for the development of new procedures. The laboratory approach to the predictive diagnosis of iron deficiency is chosen as an example of the system.

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References

  1. Grams, R. R., Johnson, E. A., and Benson, E. S., Laboratory data analysis system I-VI.Am. J. Clin. Pathol. 58:177–219, 1972.

    Google Scholar 

  2. Winkel, P., Patterns and clusters-multivariate approach for interpreting clinical chemistry results.Clin. Chem. 19:1324–1329, 1973.

    Google Scholar 

  3. Truett, J., Cornfield, J., and Kennell, W., A multivariate analysis of the risk of coronary heart disease in Framingham.J. Chron. Dis. 20:511–524, 1967.

    Google Scholar 

  4. Glick, J. H., Serum lactate dehydrogenase enzyme and total lactate dehydrogenase values in health and disease and clinical evaluation of these tests by means of discriminant analysis.Am. J. Clin. Pathol. 52:320–328, 1969.

    Google Scholar 

  5. Amenta, J. S., and Harkins, M. L., The use of discriminant functions in laboratory medicine. Evaluation of phosphate clearance studies in the diagnosis of hyperparathyroidism.Am. J. Clin. Pathol. 55:330–341, 1971.

    Google Scholar 

  6. Werner, M., Brooks, S. H., and Cohnen, G., Diagnostic effectiveness of electrophoresis and specific protein assays, evaluated by discriminate analysis.Clin. Chem. 18:116–123, 1972.

    Google Scholar 

  7. Baron, D. N., A critical look at the value of biochemical liver function tests with specific reference to discriminant function analysis.Ann. Clin. Biochem. 7:100–108, 1970.

    Google Scholar 

  8. Ramsoe, K., Tygstrup, N., and Winkel, P., The redundancy of liver tests in the diagnosis of cirrhosis estimated by multivariate statistics.Scand. J. Clin. Lab. Invest. 26:307–312, 1970.

    Google Scholar 

  9. Solberg, H. E., Skrede, S., and Blomhoff, J. P., Diagnosis of liver disease by laboratory results and discriminant analysis: Identification of best combination of laboratory tests.Scand. J. Clin. Lab. Invest. 35:713–721, 1975.

    Google Scholar 

  10. Sher, P.P., Diagnostic effectiveness of biochemical liver function tests, as evaluated by discriminant function analysis.Clin. Chem. 23:627–630, 1977.

    Google Scholar 

  11. Goldman, L., Caldera, D. L., Nussbaum, S. R., et al., Multifactorial index of cardiac risk in non-cardiac surgery.N. Engl. J. Med. 297:845–849, 1977.

    Google Scholar 

  12. Wagner, T., Tautu, P., and Wolsen, U., Problems of medical diagnosis—a bibliography.Meth. Inform. Med 17:55–74, 1978.

    Google Scholar 

  13. Beck, J. R., Cornwell, G. G., and Rawnsley, H. M., Multivariate approach to predictive diagnosis of bone marrow iron stores.Am. J. Clin. Pathol., 70:665–670, 1978.

    Google Scholar 

  14. Beck, J. R., French, E. E., Brinck-Johnsen, T., et al., Ferritin combined with other laboratory tests in the predictive diagnosis of bone marrow iron stores. Acad. Clin. Lab. Phys. Sci. annual meeting, 1978. (abstract)

  15. Cooley, W. W., and Lohnes, P. R.,Multivariate Data Analysis, Wiley, New York, 1971, pp. 49–59.

    Google Scholar 

  16. Tukey, J.,Exploratory Data Analysis, Addison-Wesley, Reading, Massachusetts, 1977, pp. v-viii.

    Google Scholar 

  17. Anderberg, M. R.,Cluster Analysis for Applications, Academic Press, New York, 1973, pp. 131–151.

    Google Scholar 

  18. McGee, V. E., The multidimensional scaling of elastic distances.Br. J. Math. Stat. Psych. 19:181–186, 1966.

    Google Scholar 

  19. Cooley, W. W., and Lohnes, P. R.,Multivariate Data Analysis. Wiley, Proc. Royal Soc. London 184:421–432, 1973.

    Google Scholar 

  20. Gleser, M. A., and Collen, M. F., Toward automated medical decisions.Comput. Biomed. Res. 5:180–189, 1972.

    Google Scholar 

  21. Horrocks, J. C., McCann, A. P., Staniland, J. R., et al., Computer aided diagnosis: Description of an adaptable system and operational experience with 2,034 cases.Br. Med. J. 2:5–9, 1972.

    Google Scholar 

  22. Knill-Jones, R. P., Stern, R. B., Grimes, D. H., et al., Use of sequential Bayesian model in diagnosis of jaundice by computer.Br. Med. J. 1:530–533, 1973.

    Google Scholar 

  23. Lipkin, M., Engle, R. L., Flehinger, B. J., et al., Computer-aided diagnosis of hematologic diseases.Ann. N. Y. Acad. Sci. 161:670–679, 1969.

    Google Scholar 

  24. Rifkin, R. D., and Hood, W. B., Bayesian analysis of electrocardiograms in exercise stress testing.N. Engl. J. Med. 297:681–685, 1977.

    Google Scholar 

  25. Galen, R. S., and Gambino, S. R.,Beyond Normality: The Predictive Value and Efficiency of Medical Diagnoses. Wiley, New York, 1975, pp. 50–51.

    Google Scholar 

  26. Beck, J. R., French, E. E., Brinck-Johnsen, T., et al., Ferritin and mean corpuscular volume in the evaluation of patients for iron deficiency, in preparation.

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Beck, J.R., Rawnsley, H.M. A multivariate data reduction system. J Med Syst 2, 171–180 (1978). https://doi.org/10.1007/BF02222317

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