Abstract
Since there is evidence that cholestyramine improves diarrheal states where failure of bile salt reabsorption would not appear significant, a study was undertaken to examine the effect of this resin on the toxicity and absorption of bacterial endotoxin. Both the toxicity of intraperitoneal injections of a cholestyramine-endotoxin suspension, and the absorption of the suspension through everted gut sacs was compared with a similar Dowex I-X8 suspension in rats. The results show that cholestyramine significantly reduces the toxicity of endotoxin when placed in the peritoneal cavity, and that it effectively inhibits the passage of51Cr labeled endotoxin through the intestinal wall.
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Supported in part by US Public Health Service Grant 1 RO1 AM-9524-01A1 and by the John A. Hartford Foundation.
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Nolan, J.P., Ali, M.V. Effect of cholestyramine on endotoxin toxicity and absorption. Digest Dis Sci 17, 161–166 (1972). https://doi.org/10.1007/BF02232738
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DOI: https://doi.org/10.1007/BF02232738