Summary
Positron emission tomography of the brain following intravenous injection of (+) (R) and (−) (S) N-[11C-methyl]nicotine showed a marked reduced uptake of both isomers, especially the (R) form, in Alzheimer patients as compared to age-matched controls. The significantly larger difference between the uptake values of the (S)- and (R)-enantiomers of11C-nicotine in Azheimer brains may be of diagnostic value.
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Nordberg, A., Hartvig, P., Lilja, A. et al. Decreased uptake and binding of11C-nicotine in brain of Alzheimer patients as visualized by positron emission tomography. J Neural Transm Gen Sect 2, 215–224 (1990). https://doi.org/10.1007/BF02257652
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DOI: https://doi.org/10.1007/BF02257652