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Deterioration of mixed cryoglobulinemia during treatment with interferon-alpha-2a

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Abstract

A 60-year-old female developed mixed cryoglobulinemia associated with liver cirrhosis caused by the hepatitis C virus. During treatment with rIFN-alpha-2a, deterioration of cryoglobulinemia was recognized. The possible mechanisms underlying the deterioration are discussed.

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References

  1. Levo Y. Cryoglobulins in patients with acute hepatitis and inflammatory bowel disease. Hepatogastroentoly 1982;29: 246–248.

    CAS  Google Scholar 

  2. Levo Y. Nature of cryoglobulinemia. Lancet 1980;1:285–287.

    CAS  PubMed  Google Scholar 

  3. Bonomo L, Casato M, Afeltra A, Caccavo D. Treatment of idiopathic mixed cryoglobulinemia with alpha interferon. Am J Med 1987;83:726–730.

    Article  CAS  PubMed  Google Scholar 

  4. Borden EC. Interferons: pleiotropic cellular modulators. Clin Immunol Immunopathol 1992;62:S18-S24.

    Article  CAS  PubMed  Google Scholar 

  5. Knox TA, Hillyer CD, Kaplan MM, Berkamn EM. Mixed cryoglobulinemia responsive to interferon-alpha. Am J Med 1991;91:554–555.

    Article  CAS  PubMed  Google Scholar 

  6. Marcellin P, Descamps V, Martinot-Peignoux M, et al. Cryoglobulinemia with vasculitis associated with hepatis C virus infection. Gastroenterology 1993;104:272–277.

    CAS  PubMed  Google Scholar 

  7. Ferr C, Zignego L, Longombardo G, et al. Effects of alpha-interferon on hepatitis C virus chronic infection in mixed cryoglobulinemia patients. Infection 1993;21:93–97.

    Google Scholar 

  8. Fauci AS, Haynes BF, Katz P. The spectrum of vasculitis: Clinical, pathologic, immunologic, and therapeutic considerations. Ann Intern Med 1987;89:660–676.

    Google Scholar 

  9. Frenkes AH, Singer DJ, Winearls CG, et al. Type II essential mixed cryoglobulinemia: Presentation, treatment, and outcome in 13 patients. Q J Med 1992;82:101–124.

    Google Scholar 

  10. Finkelman FD, Svetic A, Gresser I, et al. Regulation by interferon-alpha of immunoglobulin isotype selection and lymphokine production in mice. J Exp Med 1991;174:1179–1188.

    Article  CAS  PubMed  Google Scholar 

  11. Punnonen J, Viljanen MK. Interferon-alpha and interferon-gama as regulators of human adult and newborn B cell function. Int J Immunopharmacol 1989;11:717–723.

    Article  CAS  PubMed  Google Scholar 

  12. von Wussow P, Freund M, Block B, et al. Clinical significance of anti-IFN-alpha antibody titres during interferon therapy. Lancet 1987;II:635–636.

    Google Scholar 

  13. Antoenelli G, Currenti M, Turriziani O, Dianzani F. Neutralizing antibodies to interferon-alpha: Relative frequency in patients treated with different interferon preparations. J Infect Dis 1991;163:882–885.

    Google Scholar 

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Bojć, I., Lilić, D., Radojčić, Č. et al. Deterioration of mixed cryoglobulinemia during treatment with interferon-alpha-2a. J Gastroenterol 29, 369–371 (1994). https://doi.org/10.1007/BF02358379

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  • DOI: https://doi.org/10.1007/BF02358379

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