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Kinetics of uptake, distribution, and excretion of zinc in rats

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Abstract

A whole body pharmacokinetic model to quantify zinc uptake, distribution, and excretion in rats is developed. The novel features of the model are the large number of tissues which are included (17 tissues, plasma, and red blood cells) and the long time range (3 weeks) over which the data are simulated. The model provides adequate simulations (average error less than 10%) of the zinc concentration and excretion data after the intravenous injection of65ZnSO4. A model of this type is essential to develop a more comprehensive model to quantify zinc speciation and binding.

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Authors and Affiliations

  1. Department of Chemical Engineering, Carnegie-Mellon University, 15213, Pittsburgh, Pennsylvania

    Rakesh K. Jain & Leonard E. Gerlowski

  2. Division of Nuclear Medicine, St. Luke’s Hospital Center, New York, New York

    Jack Wang & Richard N. Pierson Jr.

Authors
  1. Rakesh K. Jain
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  2. Leonard E. Gerlowski
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  3. Jonas M. Weissbrod
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  4. Jack Wang
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  5. Richard N. Pierson Jr.
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Department of Chemical Engineering Columbia University

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Jain, R.K., Gerlowski, L.E., Weissbrod, J.M. et al. Kinetics of uptake, distribution, and excretion of zinc in rats. Ann Biomed Eng 9, 347–361 (1981). https://doi.org/10.1007/BF02364655

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