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Simultaneous measurement of stroke volume by impedance cardiography and nuclear ventriculography: Comparisons at rest and exercise

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Abstract

We have conducted four major impedance cardiography (ZCG) studies to provide data on validity, reproducibility, and sensitivity of response to interventions. The reference technique was quantitative nuclear ventriculography (NVG). Subjects were healthy young men in situations where minimally invasive and unobtrusive techniques were preferred. Interventions used included caffeine ingestion and exercise. Validity of ZCG estimates of stroke volume index (SVI, ml/m2) was tested in 35 men at rest. SVI was 49±9 by ZCG and 46±7 by NVG (r=0.82). Measurements of SVI during bicycle exercise showed no overall difference by the two methods (F=0.26, P=NS). Vascular resistance index (mean BP/CI) increased comparably by both techniques (+9.6% by ZCG and +9.7% by NVG) following caffeine (3.3 mg/kg). The reproducibility of ZCG was demonstrated in the day-to-day consistency of caffeine's effect on vascular resistance in 3 other studies (+11.9%, 12%, and 8.9%). Reliability across and within days was shown by repeated tests in the same subjects (SVI, r's=.96, .92). Conclusion: Impedance cardiography was shown to be a useful noninvasive technique for evaluation of cardiodynamics in biomedical research since it was highly reproducible and yielded equivalent results of relative changes produced by pharmacological and physical challenge. In addition, there was good agreement with NVG in absolute values for grouped data.

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References

  1. Ashburn, W.L.; Kostuk, W.J.; Karline, J.S.; Peterson, K.L.; Sobel, B.E. Left ventricular volume and ejection fraction determined by radio-nuclide angiography. Semin. Nucl. Med. 3: 165–176; 1973.

    CAS  PubMed  Google Scholar 

  2. Burow, R.D.; Wilson, M.F.; Heath, P.W.; Corn, C.R.; Amil, A.; Thadani, U. Influence of attenuation on radionuclide stroke volume determinations J. Nucl. Med. 23: 781–795; 1982.

    CAS  PubMed  Google Scholar 

  3. Ebert, T.J.; DeMeersman, R.E.; Seip, R.L.; Snead, D.B.; Schelhorn, J.J. Signal-averaged impedance cardiograms during continuous exercise in man. Unpublished manuscript, 1986, VA Medical Center, Milwaukee, WI.

    Google Scholar 

  4. Ebert, T.J.; Eckberg, D.L.; Vetrovic, G.M.; Cowley, M.J., Impedance cardiograms reliably estimate beat-by-beat changes in left ventricular stroke volume in humans. Cardiovasc. Res. 18: 354–360; 1984.

    CAS  PubMed  Google Scholar 

  5. Kisakevitch, P.N.; Gollan, F.; McDermott, J.; Aranda, J. Continuous noninvasive cardiac monitoring of cardiac function. Proc. of the First Annual Symposium on Computer Applications in Medical Care. IEEE:77CH1270-1278C: 325–335; 1977.

  6. Kubicek, W.G.; Kottke, F.J.; Ramos, M.V.; Patterson, R.P.; Witsoe, D.A.; Labree, J.W.; Remole, W.; Layman, T.E.; Schwening, H.; Garamella, J.T., The Minnesota impedance cardiograph — theory and applications. Biomed. Engr. 9: 410–416; 1974.

    CAS  Google Scholar 

  7. Lovallo, W.R.; Pincomb G.A.; Sung, B.H.; Sausen, K.P.; Wilson, M.F. Cardiovascular effects of mental stress in men high and low in risk of hypertension. Circulation 76(Suppl II): IV-11; 1987.

    Google Scholar 

  8. Pincomb, G.A.; Lovallo, W.R.; Passey, R.B.; Whitsett, T.L.; Silverstein, S.M.; Wilson, M.F. Effects of caffeine on vascular resistance, cardiac output and myocardial contractility in young men. Am. J. Cardiol. 56: 119–122; 1985.

    Article  CAS  PubMed  Google Scholar 

  9. Pincomb, G.A.; Lovallo, W.R.; Passey R.B.; Wilson, M.F. Effect of behavior state on caffeine's ability to alter blood pressure. Am. J. Cardiol. 61: 798–802; 1988.

    Article  CAS  PubMed  Google Scholar 

  10. Secher, N.J.; Thomsen, A.; Arnsbo, P. Measurement of rapid changes in cardiac stroke volume. An evaluation of the impedance cardiography method. Acta Anaesthes. Scand. 21: 353–358; 1977.

    CAS  Google Scholar 

  11. Strauss, H.W.; Zaret, B.L.; Hurley, P.J.; Natarajan, T.K.; Pitt, B. A scintiphotographic method for measuring left ventricular ejection fraction in man without cardiac catheterization. Am. J. Cardiol. 28: 575–580; 1971.

    Article  CAS  PubMed  Google Scholar 

  12. Van Fraechem, J.H.P. Stroke volume and systolic time interval adjustments during bicycle exercise. J. Appl. Physiol. 46: 588–592; 1979.

    Google Scholar 

  13. Wilson M.F.; Lovallo, W.R.; Pincomb, G.A. Noninvasive measurement of cardiac functions. In: Schneiderman, N.; Weiss, S.; Kaufman, P.; eds. Handbook of Research Methods in Cardiovascular Behavioral Medicine. New York: Plenum Press; pp. 23–50; 1989.

    Google Scholar 

  14. Wilson, M.F.; Sung, B.H.; Pincomb, G.A.; McDaniel, K.B.; Lovallo, W.R. Caffeine exaggerates hyptertensive response to maximum exercise in normal young men at risk for hypertension. Circulation 76(Suppl II): IV-11; 1987.

    Google Scholar 

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Authors and Affiliations

  1. Research Service, VA Medical Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

    Michael F. Wilson M.D., Gwendolyn A. Pincomb & William R. Lovallo

  2. Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

    Michael F. Wilson M.D. & Bong Hee Sung

  3. Departments of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

    Bong Hee Sung

  4. College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

    Gwendolyn A. Pincomb & William R. Lovallo

Authors
  1. Michael F. Wilson M.D.
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  2. Bong Hee Sung
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  3. Gwendolyn A. Pincomb
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  4. William R. Lovallo
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Additional information

Supported by funds from the National Heart, Lung, and Blood Institute, HL32050; and the Medical Research Service, Department of the Veterans Affairs.

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Wilson, M.F., Sung, B.H., Pincomb, G.A. et al. Simultaneous measurement of stroke volume by impedance cardiography and nuclear ventriculography: Comparisons at rest and exercise. Ann Biomed Eng 17, 475–482 (1989). https://doi.org/10.1007/BF02368067

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  • DOI: https://doi.org/10.1007/BF02368067

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