Abstract
Sexual behavior and some of its consequences were assessed in female rats which, with advancing age, had come to exhibit persistent vaginal estrus (PVE). Sexual receptivity, defined by the animal’s readiness to exhibit lordosis when mounted, was comparable across all ages evaluated. However, sexual proceptivity, defined by measures indicative of the female’s seeking mating opportunities, was determined to be much suppressed in 18 to 20 month old PVE females compared to either younger cyclic females or 12 to 15 month old PVE females. Mating disrupted the PVE pattern. The length of time animals remained out of estrus was positively correlated with the number of intromissions achieved by the male. However, pregnancy was not observed in any of the PVE females and examination of their ovaries and the responses of their uteri to traumatization provided no evidence of progestational responses in these animals. The behavioral data indicate that with continued exposure to the hormonal conditions of PVE there is a suppression of systems mediating the proceptive components of sexual behavior in female rats. It is suggested that changes in the concentrations of pituitary and/or ovarian hormones reported to occur as PVE rats continue to age may account for these changes in behavior.
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References
Aschheim, P.: Aging in the hypothalamic-hypophyseal-ovarian axis in the rat, in Hypothalamus Pituitary and Aging, edited by Everitt, A. V. and Burgess, J. A., Springfield, IL, Charles C. Thomas, 1976, pp. 376–418.
Cooper, R. L. and Linnoila, M.: Sexual behavior in aged, non-cycling female rats. Physiol. Behav., 18: 573–576, 1977.
Hendricks, S. E., Lehman, J. L., and Oswalt, B. L.: Effects of copulation on reproductive function in aged female rats. Physiol. Behav., 23: 267–272, 1979.
Meites, J., Huang, H. H., and Simpkins, J. W.: Recent studies on neuroendocrine control of reproductive senescence in rats, in Aging, Vol. 4: The Aging Reproductive System, edited by E. L. Schneider, New York, Raven Press, 1978, pp. 213–235.
Cooper, R. L.: Sexual receptivity of aged female rats. Horm. Behav., 9: 321–333, 1977.
Peng, M. T., Chuong, C. F., and Peng, Y. M.: Lordosis of senile female rats. Neuroendocrinol., 24: 317–324, 1977.
Beach, F. A.: Sexual attractivity, proceptivity, and receptivity in female mammals. Horm. Behav., 7: 105–138, 1976.
Lu, K. H., Hopper, B. R., Vargo, T. M.,and Yen, S. S. C: Chronological changes in sex steroid gonadotropin and prolactin secretion in aging female rats displaying different reproductive states. Biol. Reprod., 21: 193–203, 1979.
Lisk, R. D.: Progesterone: biphasic effects on the lordosis response in adult or neonatally gonadectomized rats. Neuroendocrinol. 5: 149–160, 1969.
Morin, L.: Progesterone: inhibition of rodent sexual behavior. Physiol. Behav., 18: 701–715, 1976.
Crowley, W. R., Rodrigues-Sierra, J. F. and Komisaruk, B. R.: Hypophysectomy facilitates sexual behavior in female rats. Neuroendocrinol. 20: 328–338, 1976.
Beach, F. F. and Jordan, L.: Sexual exhaustian and recovery in the male rat. Quart. J. Exp. Psychol., 8: 121–133, 1956.
Henrik, E. and Gerall, A. A.: Facilitation of receptivity in estrogen-primed rats during successive mating tests with progesten and methysergide. J. comp. physiol. Psychol., 90: 590–600, 1976.
De Feo, V. J.: Temporal aspects of uterine sensitivity in pseudopregnant or pregnant rats. Endocrinology, 72: 305–316, 1963.
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Borchardt, C.M., Lehman, J.R. & Hendricks, S.E. Sexual behavior and some of its physiological consequences in persistently estrous aged female rats. AGE 3, 59–63 (1980). https://doi.org/10.1007/BF02431729
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DOI: https://doi.org/10.1007/BF02431729