Skip to main content
SpringerLink
Log in

Free-radical mechanisms in cerebral pathologies (Review)

  • Reviews
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The current status of knowledge about the roles played by radical reactions in the pathogenesis of cerebral pathologies is reviewed, and it is shown that these reactions are of key importance to the damage sustained by cellular structures of the central nervous system. Novel approaches to the management of cerebral disorders, based on the use of antioxidants, are considered.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M. P. Andrusenko, V. I. Dikaya, N. B. Zharkova, and et. al.,Byull. Eksp. Biol. Med.,117, No 2, 199–200 (1994).

    Google Scholar 

  2. E. B. Burlakova,Free-Radical Oxidation in Health and Disease [in Russian], Moscow (1976), pp. 18–19.

  3. N. V. Gulyaeva,Lipid Peroxidation in the Brain during Adaptation to Stress (Author's synopsis of doctoral dissertation) [in Russian], Moscow (1989).

  4. N. V. Gulyaeva,Biol. Nauki, No 4, 5–14 (1989).

    Google Scholar 

  5. N. V. Gulyaeva, A. B. Obidin, and I. P. Levshina,Dokl. Akad. Nauk SSSR,300, 748–752 (1988).

    CAS  Google Scholar 

  6. N. V. Gulyaeva and I. P. Levshina,Byull. Eksp. Biol. Med.,111, No 6, 568–569 (1991).

    Google Scholar 

  7. N. V. Gulyaeva, M. B. Plotnikov, and V. V. Nikonov,Dimethyl Sulfoxide in Experimental and Clinical Studies (Stress, Intracerebral Hemorrhage, Myocardial Infarction) [in Russian], Tomsk (1992), pp. 7–25.

  8. N. G. Davitashvili, A. N. Erin, and L. L. Prilipko,Biokhimiya,51, No 3, 472–477 (1986).

    CAS  Google Scholar 

  9. A.N. Erin,Structural and Functional Stabilization of Brain Membranes with Vitamin E (Phenomenology and Molecular Mechanisms) (Author's synopsis of doctoral dissertation) [in Russian], Moscow (1991).

  10. E. M. Kreps,Lipids of Cell Membranes [in Russian], Leningrad (1981).

  11. G. N. Kryzhanovskii, E. V. Nikushkin, E. V. Braslavskii, and et al.,Byull. Eksp. Biol. Med.,89, No 1, 14–16 (1980).

    Article  CAS  Google Scholar 

  12. M. L. Libe, V. I. Brusovanik, L. Yu. Ukhin,et al.,,112, No 7, 11–12 (1991).

    CAS  Google Scholar 

  13. F. Z. Meerson, in:Physiology of Adaptive Processes [in Russian], Moscow (1986), pp. 77–123, 521–621.

  14. F. Z. Meerson, V. E. Kagan, L. L. Prilipko,et al., Byull. Eksp. Biol. Med.,88, 404–406 (1979).

    CAS  Google Scholar 

  15. F. Z. Meerson, Yu. V. Arkhipenko, and V. V. Didenko,,106, No 11, 542–544 (1988).

    CAS  Google Scholar 

  16. E. V. Nikushkin,Lipid Peroxidation in Epilepsy. Antioxidants in Anticonvulsive Therapy (Author's synopsis of doctoral dissertation) [in Russian], Moscow (1991).

  17. E. V. Nikushkin,Neirokhimiya,8, No 1, 124–145 (1989).

    CAS  Google Scholar 

  18. L. L. Prilipko,Role of Lipid Peroxidation Processes in the Damage Sustained by Membrane Structures of the Brain in Stress and Hyperoxia (Author's synopsis of doctoral dissertation) [in Russian], Moscow (1983).

  19. A. N. Pyatnitskii, V. V. Bondar, and O. B. Yakovleva,Byull. Eksp. Biol. Med.,117, No 2, 218 (1994).

    Google Scholar 

  20. Free-Radical Mechanisms of Cerebral Pathologies: Theoretical and Practical Aspects. Abstracts of papers submitted to the First National Conference,Ibid. Byull. Eksp. Biol. Med.,117, No 2, 198–224 (1994).

  21. N. V. Spiricheva, M. V. Aksenova, O. N. Orlov,et al.,,107, No 6, 680–682 (1989).

    CAS  Google Scholar 

  22. O. I. Aruoma, H. Kaur, and B. Halliwell,J. R. Soc. Health,1, 172–177 (1991).

    Google Scholar 

  23. G. Cohen, in:Pathology of Oxygen, New York (1982), pp. 115–126.

  24. A. N. Erin, N. A. Andreeva, and I. V. Viktorov,Excerpta Med.,998, 433–435 (1993).

    Google Scholar 

  25. P. V. Evans,Brit. Med. Bull.,49, 577–587 (1993).

    PubMed  CAS  Google Scholar 

  26. N. V. Gulyaeva,Man. Neuron, Modeling,1, 5 (1992).

    Google Scholar 

  27. B. Halliwell,Drugs,42, No 4, 569–605 (1991).

    PubMed  CAS  Google Scholar 

  28. J. B. Lohr, J. L. Cadet, R. J. Wyatt,et al., Lancet,1, No 8538, 913–914 (1987).

    Article  PubMed  CAS  Google Scholar 

  29. W. A. Pryor, in:Free Radicals in Molecular Biology, Aging and Disease, New York (1984), pp. 13–41.

  30. J. Topinka, B. Binkova, R.J. Sram, and A.N. Erin,Mutat. Res.,225, 131–136 (1989).

    Article  PubMed  CAS  Google Scholar 

  31. Vitamin E Abstract, in:VERIS, Ed. M. Horvitt, Illinois, USA (1982–1993).

Download references

Author information

Authors and Affiliations

  1. Mental Health Research Center, Russian Academy of Medical Sciences, Moscow

    A. N. Erin

  2. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow

    N. V. Gulyaeva

  3. Central Clinical Hospital of the Russian Government Medical Center, Moscow

    E. V. Nikushkin

Authors
  1. A. N. Erin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. V. Gulyaeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. V. Nikushkin
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, No 10, pp. 343–348, October, 1994

Rights and permissions

Reprints and permissions

About this article

Cite this article

Erin, A.N., Gulyaeva, N.V. & Nikushkin, E.V. Free-radical mechanisms in cerebral pathologies (Review). Bull Exp Biol Med 118, 1045–1049 (1994). https://doi.org/10.1007/BF02446456

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02446456

Key Words

Search

Navigation