Abstract
The operation and construction of a microelectrode amplifier intended for routine use in studying the electrical behaviour of a cell membrane under various stimulation conditions are described in this paper. For the sake of versatility the microelectrode amplifier includes a stimulator, iontophoretic current generator, membrane resting potential and electrode resistance meters, filters and capacitance neutralisation circuits in addition to the amplifiers. Some measurements to verify the desired operation are included.
Similar content being viewed by others
References
Colburn, T. R. andSchwarz, E. A. (1972) Linear voltage control of current passed through a micropipette with variable resistance.Med. & Biol. Eng.,10, 504–509.
Hauser, S. E. andCohen, S. A. (1976) An isolated current monitor for iontophoresis.ISA Trans.,18 (3), 253–257.
Reuben, J. P., Purpura, D. P., Benneth, M. V. andKandel, E. R. (Eds.) (1975)Electrobiology of nerve, synapse and muscle. Rawen Press, New York, 63–107.
Thomas, M. V. (1977) Microelectrode amplifier with improved method of input-capacitance neutralisation.Med. & Biol. Eng. & Comput.,15, 450–454.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Peltoranta, M., Malmivuo, J., Nieminen, K. et al. Microelectrode amplifier for intracellular stimulation and recording. Med. Biol. Eng. Comput. 21, 731–738 (1983). https://doi.org/10.1007/BF02464036
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02464036