Abstract
In attempts to predict the recurrence of gastric cancer, postoperative changes in serum carcinoembryonic antigen (CEA) levels are monitored in our clinic by radioimmunoassay (Dainabot, Japan). Recurrences are suspected when serum CEA levels are 4 ng/ml, in the postoperative period. Out of 34 patients in whom there were increases in serum CEA, 18 were confirmed to have a recurrence and 15 of these 18 patients were assessed accurately by serial postoperative levels of CEA, two patients died of a recurrence after elevation of serum CEA levels. Thus, recurrence was predicted in 17 out of 34 patients (50 per cent) and in 12 out of 17 patients there was a metastasis to the liver. In 14 out of 34 patients there are no signs of recurrence 9 to 25 months after serum CEA elevations.
Similar content being viewed by others
References
Gold, P. and Freedman, S.O.: Demonstration of tumor antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J. Exp. Med. 121: 439–462, 1965.
Zamcheck, N.: Carcinoembryonic antigen; Quantitative variations in circulating levels in benign and malignant digestive tract diseases. Adv. Int. Med. 19: 413–433, 1974.
Booth, S.N., Jamieson, G.C., King, J.P. Leonard, J., Oates, G.D., and Dykes, P.W.: Carcinoembryonic antigen in management of colorectal carcinoma. Brit. Med. J. 4: 183–187, 1974.
Sugarbaker, P.H., Zamchek, N. and Moore, F.D.: Assessment of serial Carcinoembryonic antigen (CEA) assay in postoperative detection of recurrent colorectal cancer. Cancer 38: 2310–2315, 1976.
Mackay, A.M., Patel, S., Carter, S., Stevens, U., Laurence, D.J.R., Cooper, E.H. and Neville, A.M.: Role of serial plasma CEA assays in detection of recurrent and metastatic colorectal carcinomas. Brit. Med. J. 4: 382–385, 1974.
Mach, J.P., Jaeger, P., Bertholet, M.M., Ruegsegger, C.H., Loosli, R.M. and Pettavel, J.: Detection of recurrence of large-bowel carcinoma by radioimmunoassay of circulating Carcinoembryonic antigen (C.E.A.). Lancet 2: 533–540, 1974.
Wanebo, H.J., Stearns, M. and Schwartz, M.K.: Use of CEA as an indicator of early recurrence and as a guide to a selected second-look procedure in patients with colorectal cancer. Ann. Surg. 188: 481–493, 1978.
Steele, Jr., Zamcheck, N., Wilson, R., Mayer, R., Lokich, L., Rau, P. and Maltz, J.: Results of CEA-indicated second-look surgery for recurrent colorectal cancer. Am. J. Surg. 139: 544–548, 1980.
Iwamatsu, M., Saito, Y., Matsuguchi, T., Tamada, R., Soejima, K. and Inokuchi, K.: Early detection of recurrence of gastric cancer by serial plasma Carcinoembryonic antigen assays. Cell. Mol. Biol. 26: 287–291, 1980.
Hirai, H.: Collaborative clinical study of Carcinoembryonic antigen in Japan. Cancer Res. 37: 2267–2274, 1977.
Laurence, D.J.R., Stevens, U., Bettelheim, R., Darcy, D., Leese, C., Turberville, C., Alexander, P., Johns, E.W. and Munro Neville, A.: Role of plasma Carcinoembryonic antigen in diagnosis of gastrointestinal, mammary and bronchial carcinoma. Brit. Med. J. 3: 605–609, 1972.
Martin, E.W., Cooperman, M., King, G., Rinker, L., Carey, L.C. and Minton, J.P.: A retrospective and prospective study of serial CEA determinations in the early detection of recurrent colon cancer. Am. J. Surg. 137: 167–169, 1979.
Stabb, H.J., Anderer, F.A., Stumpf, E. and Fisher, R.: Slope analysis of the postoperative CEA time course and its possible application as an aid in diagnosis of disease progression in gastrointestinal cancer. Am. J. Surg. 136: 322–327, 1978.
Zamcheck, N., Doos, W.G., Prudente, R., Lurie, B.B. and Gottlieb, L.S.: Prognostic factors in colon carcinoma. Human Pathol. 6: 31–45, 1975.
Kano, T., Kumashiro, R., Tamada, R., Kodama, Y. and Inokuchi, K.: Late results of postoperative long term cancer chemotherapy for advanced carcinoma of the stomach. Jpn. J. Surg. 11: 291–296, 1981.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tamada, R., Hiramoto, Y., Abe, Y. et al. Serial determinations of carcinoembryonic antigen for early detection of recurrent gastric cancer. The Japanese Journal of Surgery 12, 429–433 (1982). https://doi.org/10.1007/BF02469833
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02469833