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Programmable nanoampere constant current sources for iontophoresis

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Abstract

A number of constant current sources for microiontophoretic drug application to neurones are described, and the limitations of these discussed.

Some practical constant current circuits are also described which have in addition to constant current generation, capabilities permitting pulsed application of current, as well as programming of the current by both analogue and digital signals, thus allowing closed-loop control of drug application.

Sommaire

On décrit et l'on discute des limitations d'un nombre de sources de courant constant pour l'application de drogue microiontophorétique à des neurones.

On décrit également quelques circuits de courant constant pratiques qui en plus de la génération d'un courant constant sont capables de permettre l'application pulsée de courant, ainsi que la programmation du courant par signaux analogiques et digitaux, permettant ainsi le contrôle par chaine fermée de l'application de drogues.

Zusammenfassung

Es werden eine Anzahl konstanter Stromquellen für mikroelektrophoretische Verwendung von Arzneimitteln für Neuronen beschrieben.

Auch werden einige praktische konstante Stromschaltungen beschrieben, welche ausser Erzeugung konstanten Stroms die Fähigkeit besitzen, Verwendung von Stromimpulsen sowie Programmierung des Stroms sowohl durch analoge wie digitale Signale zu ermöglichen und damit die Stromkreiskontrolle von Arzneianwendung gestatten.

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Authors and Affiliations

  1. Department of Physiology, University of Manitoba, Winnipeg 3, Manitoba, Canada

    H. J. Spencer

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  1. H. J. Spencer
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Spencer, H.J. Programmable nanoampere constant current sources for iontophoresis. Med. & biol. Engng. 9, 693–702 (1971). https://doi.org/10.1007/BF02474650

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  • DOI: https://doi.org/10.1007/BF02474650

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