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Preparation of carbon-11 labelled acetate and palmitic acid for the study of myocardial metabolism by emission-computerised axial tomography

  • Short-lived Radionuclides
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Abstract

Methods have been developed for the labelling of acetate and palmitic acid with the positron-emitting radionuclide,11C (T=20.4 min). Labelling was achieved via carbonation of the appropriate alkyl magnesium bromide (methyl magnesium bromide or n-pentadecyl magnesium bromide) with11C-labelled carbon dioxide produced by the14N(p, α)11C nuclear reaction. The radiochemical yield and speed of each method of labelling are such that a radiochemically pure product is obtained in injectable form and in activity (>10 mCi) suitable for the study of myocardial metabolism by emission-computerised axial tomography. High pressure liquid chromatography and thin layer chromatography were used to assess the radiochemical purity of each radiopharmaceutical. The specific activity of11C-labelled acetate was estimated by an enzymic procedure to be greater than 0.5 Ci/μmole.

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Authors and Affiliations

  1. Medical Research Council Cyclotron Unit, Hammersmith Hospital, Ducane Road, W12 OHS, London, England

    V. W. Pike & M. N. Eakins

  2. Royal Postgraduate Medical School, Hammersmith Hospital, Ducane Road, W12 OHS, London, England

    R. M. Allan & A. P. Selwyn

Authors
  1. V. W. Pike
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  2. M. N. Eakins
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  3. R. M. Allan
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  4. A. P. Selwyn
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Pike, V.W., Eakins, M.N., Allan, R.M. et al. Preparation of carbon-11 labelled acetate and palmitic acid for the study of myocardial metabolism by emission-computerised axial tomography. J. Radioanal. Chem. 64, 291–297 (1981). https://doi.org/10.1007/BF02518360

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  • DOI: https://doi.org/10.1007/BF02518360

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