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The effect of prior breast biopsy method and concurrent definitive breast procedure on success and accuracy of sentinel lymph node biopsy

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Abstract

Background

It has been suggested that sentinel lymph node (SLN) biopsy for breast cancer may be less accurate after excisional biopsy of the primary tumor compared with core needle biopsy. Furthermore, some have suggested an improved ability to identify the SLN when total mastectomy is performed compared with lumpectomy. This analysis was performed to determine the impact of the type of breast biopsy (needle vs. excisional) or definitive surgical procedure (lumpectomy vs. mastectomy) on the accuracy of SLN biopsy.

Methods

The University of Louisville Breast Cancer Sentinel Lymph Node Study is a prospective multi-institutional study. Patients with clinical stage T1–2, N0 breast cancer were eligible. All patients underwent SLN biopsy and completion level I/II axillary dissection. Statistical comparison was performed by χ2 analysis.

Results

A total of 2206 patients were enrolled in the study. There were no statistically significant differences in SLN identification rate or false-negative rate between patients undergoing excisional versus needle biopsy. The SLN identification and false-negative rates also were not statistically different between patients who had total mastectomy compared with those who had a lumpectomy.

Conclusions

Excisional biopsy does not significantly affect the accuracy of SLN biopsy, nor does the type of definitive surgical procedure.

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Authors and Affiliations

  1. Division of Surgical Oncology, Department of Surgery J. Graham Brown Cancer Center, University of Louisville School of Medicine, 529 S. Jackson St., No. 318, 40202, Louisville, KY

    Sandra L. Wong MD, Michael J. Edwards MD, Celia Chao MD, Diana Simpson RN & Kelly M. McMasters MD, PhD

  2. Park Nicollet Clinic, Minneapolis, Minnesota

    Todd M. Tuttle MD

  3. the Latter Day Saints Hospital, Salt Lake City, Utah

    R. Dirk Noyes MD

  4. the St. Mary's Medical Center and Deaconess Hospital, Evansville, Indiana

    David J. Carlson MD

  5. Breast Surgeons of North Texas, Dallas, Texas

    Alison L. Laidley MD & Terre Q. McGlothin MD

  6. Surgical Clinic Associates, Jackson, Mississippi

    Philip B. Ley MD

  7. Norton Hospital, Louisville, Kentucky

    C. Matthew Brown MD

  8. Kettering Hospital, Dayton, Ohio

    Rebecca L. Glaser MD

  9. General Surgeons Inc., Richmond, Indiana

    Robert E. Pennington MD

  10. Presbyterian Hospital, Charlotte, North Carolina

    Peter S. Turk MD

Authors
  1. Sandra L. Wong MD
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  2. Michael J. Edwards MD
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  3. Celia Chao MD
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  4. Todd M. Tuttle MD
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  5. R. Dirk Noyes MD
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  6. David J. Carlson MD
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  7. Alison L. Laidley MD
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  8. Terre Q. McGlothin MD
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  9. Philip B. Ley MD
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  10. C. Matthew Brown MD
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  11. Rebecca L. Glaser MD
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  12. Robert E. Pennington MD
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  13. Peter S. Turk MD
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  14. Diana Simpson RN
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  15. Kelly M. McMasters MD, PhD
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the University of Louisville Breast Cancer Study Group

Corresponding author

Correspondence to Kelly M. McMasters MD, PhD.

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Wong, S.L., Edwards, M.J., Chao, C. et al. The effect of prior breast biopsy method and concurrent definitive breast procedure on success and accuracy of sentinel lymph node biopsy. Annals of Surgical Oncology 9, 272–277 (2002). https://doi.org/10.1007/BF02573065

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  • DOI: https://doi.org/10.1007/BF02573065

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