Summary
The chief cells of the gastrin-stimulated gastric mucosa of human and dog were observed under a light and electron microscope. Four μg/kg AOC-tetragastrin were given parenterally by a single shot to a man and three dogs respectively. Pepsinogen in the gastric mucosa increased at the wash-out stage and at the following dynamic equibrium stage of the chief cell secretion cycle after the administration of AOC-tetragastrin. During those stages, the chief cells released zymogen granules intensively. As the main ultrastructural process for releasing the zymogen granules, the emiocytosis in man and the apical cytoplasm dissociation in dog were discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Misaki F, Murakami K: Heterogeneity and secretion of pepsinogen, in “Pathophysiology of Gastric Secretion” edited by Miyoshi A et al pp 83–94, Mizunoshuppan, Tokyo, 1971 (in Japanese)
Seki H: A study on normal pepsin secretion, comparative effects of histalog and tetragastrin, and electron microscopy of the chief cells before and after stimulation. Jap J Gastroenterology 71: 135–150, 1974 (Sammary in English)
Degraef L: Physiology and physiopathology of sulfated glycoprotein and sulfated polysaccharide secretion by the gastric mucosa in the dog, in “Peptic Ulcer” edited by Pfeiffer CJ pp 155–161, Lippincott, Philadelphia, 1971
Gusek W: Zur ultramikroskopischen Cytologie der Belegzellen in der Magenschliemhaut des Menschen. Z. Zellforsch 55: 790–809, 1961.
Lillibridge CB: The fine structure of normal human gastric mucosa. Gastroenterology 47: 269–290, 1964
Meriel P, Darnaud C, Denard Y, et al: Ultrastructure de la muqueuse gastrique chez le cobaye et chez l’homme. Path Biol (Paris) 9: 1273–1290, 1961.
Sano M: Electron microscopic studies on endocrine cells and exocrine cells in gastric mucosa of rats. II. Morphological changes in chief cells and parietal cells after fasting, refeeding and electrical vagal stimulation. Arch Jap Chir 45: 265–278, 1976
Hirschowitz B: Secretion of pepsinogen, in “Handbook of Physiology, Section 6, Alimentary Canal II” edited by Code CF, pp 889–918, American Physiological Society, Washington, 1967
Heiander HF: Ultrastructure of gastric fundus glands ofrefedmice. J Ultrastruc Res 10: 160–175, 1964
Menzies G: The effects of strvation, and feeding following starvation, on the pepsinogen granules of rat’s stomach. J Path Bac 83: 475–490, 1962
Shibasaki S: Experimental cytological and electronmicroscopic studies on the rat gastric mucosa. Arch histol Jap 21: 251–288, 1961
Chiao SF, Weisberg, H: Ultrastructure of the gastric mucosa in patients with atrophic gastritis and pernicious anemia. Gastroenterology 59: 36–45, 1970
Fujita H, Kataoka K: The pepsin secretion cells, in “Basic and Clinical Sciences on the Pepsin” edited by Miyoshi A et al pp 21–32, Shinjukushobo, Tokyo, 1974 (in Japanese)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Machino, M., Aoike, A., Ikeuchi, H. et al. Fine morphology of the secretory mode of the tetragastrin-stimulated chief cells of human and dog gastric mucosa. Gastroenterol Jpn 13, 184–189 (1978). https://doi.org/10.1007/BF02773662
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02773662