Abstract
The interaction of the vanadyl (IV) (VO2+) cation with carnosine (the dipeptide β-alanyl-histidine) has been investigated by electron absorption spectroscopy at high ligand-to-metal ratios and at different pH values. The results show that in the range 6.0–8.5, the cation interacts with the imidazole group of four different carnosine molecules and points to the presence of an axially coordinated water molecule. These suppositions were confirmed by the behavior of the VO2+/imidazole system, which was investigated under similar experimental conditions, and supported by previous ENDOR (electron-nuclear double resonance) results. The study was complemented with additional measurements using the glycylglycine, glycylglycine/imidazole, and histidine systems as ligands.
Similar content being viewed by others
References
A. Rosenberg,Biochim. Biophys. Acta 45, 297 (1960).
A. Rosenberg,Ark. Kemi. 17, 25 (1961).
A. Rosenberg,Arch. Biochem. Biophys. 88, 83 (1960).
R. J. Sundberg and R. B. Martin,Chem Rev. 74, 471 (1974).
H. C. Freeman and J. T. Szymanski,Acta Crystallogr. 22, 406 (1967).
R. E. Viola, C. R. Hartzell, and J. J. Villafranca,J. Inorg. Biochem. 10, 281 (1979).
R. E. Viola, C. R. Hartzell, and J. J. Villafranca,J. Inorg Biochem. 10, 293 (1979).
E. J. Baran, B. S. Parajón-Costa, T. Rojo, R. Sáez-Puche, F. Fernández, R. M. Tótaro, M. C. Apella, S. B. Etcheverry, and M. H. Torre,J. Inorg. Biochem. 58, 279 (1995).
M. Fritzche, V. Vergopoulos and D. Rehder,Inorg. Chim. Acta 211, 11 (1993).
K. Kustin and I. Macara,Comments Inorg. Chem. 2, 1 (1982).
N.D. Chasteen,Vanadium in Biological Systems, Kluver, Dordrecht (1990).
D. Rehder,Angew Chem. internat. edit. 30, 148 (1991).
H. Sigel and A. Sigel, ed.,Metal Ions in Biological Systems, vol. 31:Vanadium and its Role in Life, Marcel Dekker, New York (1995).
E. J. BaranQuimica Bionorgánica, McGraw Hill/Interamericana de España S. A., Madrid (1995)
C. J. Ballhausen and H. B. Gray,Inorg. Chem. 1, 111 (1962).
C. F. Mulks, B. Kirste, and H. van Willigen,J. Am. Chem. Soc. 104, 5906 (1982).
N. D. Chasteen, inBiological Magnetic Resonance, Resonance, L. J. Berliner and J. Reuben, eds., vol. 3, Plenum, New York (1981).
C. R. Johnson and R. E. Shepherd,Bioinorg. Chem. 8, 115 (1978).
L. J. Calviou, J. M. Arber, D. Collinson, C. D. Garner and W. Clegg,J. Chem. Soc. Chem. Comm. 1992, 654.
R. Driver and W. R. Walker, Aust, J. Chem.21, 671 (1968).
J. D. Bell, H. C. Freeman, A. M. Wood, P. Driver and W. R. Walker,Chem. Comm. 1969, 1441.
J. Costa Pessoa, S. M. Luz, R. Duarte, J. J. G. Moura and R. D. Gillard,Polyhedron 12, 2857 (1993).
J. J. R. Frausto da Silva and R. J. P. Williams,The Biological Chemistry of the Elements, Clarendon, Oxford (1991).
J. Costa Pessoa, S. M. Luz, I. Cavaco and R. D. Gillard,Polyhedron 13, 3174 (1994).
K. A. Connors,Binding Constants, J. Wiley, New York (1987).
K. Wüthrich,Helv. Chim. Acta 48, 779 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ferrer, E.G., Williams, P.A.M. & Baran, E.J. Interaction of the vanadyl (IV) cation with carnosine and related ligands. Biol Trace Elem Res 55, 79–87 (1996). https://doi.org/10.1007/BF02784170
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02784170