Abstract
We carried out a balance study to examine the effects of isomaltulose, lactose, isomalt, and isomaltulose-based oligomers (IBOs) on mineral (calcium, magnesium, phosphorus, and iron) absorption and retention. Four-week-old male Wistar rats were divided into five groups of six rats each and fed a basal diet or diet the containing either 5% isomaltulose, 5% lactose, 5% isomalts or isomaltulose-based oligomers (IBOs) ad libitum for 16 d. After 1 wk, the animals were subjected to a 5-d mineral (calcium, magnesium, phosphorus, and iron) balance study. The isomalt feeding, as well as the IBOs feeding, led to significantly elevated mineral absorption and retention. On the other hand, lactose feeding, widely known to enhance calcium absorption, increased only calcium absorption and isomaltulose feeding did not affect mineral absorption or retention. The organic acids in cecum contents were increased by IBOs or isomalt feeding. Succinic and acetic acids in cecum contents were significantly increased by IBOs feeding. Similarly, succinic acetic, and i-valeric acids and total amount of organic acid in cecum content were significantly increased by isomalt feeding. Although the organic acids in cecum contents were increased by IBOs or isomalt feeding, the PH values and acidity in cecum contents were not changed by IBOs or isomalt feeding. The effect of addition of various organic acids to the mucosal fluid was examined with in vitro study using a hindgut segment. By the addition of acetic acid, and butyric acid, the mineral (calcium, magnesium, and phosphorus) uptake was increased.
Similar content being viewed by others
References
F. W. Lengeman, C. L. Comar, and R. H. Wasserman, Absorption of calcium and strontium from milk and nonmilk diets,J. Nutr. 61, 591–583 (1957).
F. W. Lengeman, R. H. Wasserman, and C. L. Comar, Studies on the enhancement of radiocalcium and radiostrontium absorption by lavtose in the rat,J. Nutr. 68, 443–456 (1959).
R. H. Wasserman, and C. L. Comar, Carbohydrates and gastrointestinal absorption of radiostrontium and radiocalcium in the rat,Proc. Soc. Exptl. Biol. Med. 101, 314–317 (1959).
O. W. Vaughan, and L. J. Filer, Jr., The enhancing action of certain carbohydrates on the intestinal absorption of calcium in the rat.J. Nutr. 71, 10–14 (1960).
C. Andrieux, E. Sacqet, and L. Gueguen, Microbial flora in the digestive tract and action of lactose on mineral metabolism,Reprod. Nutr. Develop. 22, 387 (1982).
C. Andrieux, and E. Sacquet, Effect of microflora and lactose on the absorption of calcium, phosphorus and magnesium in the hindgut of the rat,Reprod. Nutr. Develop. 23, 259 (1983).
T. Goda, M. Yamada, S. Takase, and N. Hosoya, Effect of maltitol intake on intestinal calcium absorption in the rat,J. Nutr. Sci. Vitaminol. 38, 277–286 (1992).
T. Goda, S. Takase, and N. Hosoya, Maltitol-induced increase of transeptithelial transport of calcium in rat small intestine,J. Nutr. Sci. Vitaminol. 39, 589–595 (1993).
T. Ooshima, A. Izumitani, S. Sobue, N. Okahashi, and S. Hamada, Non-cariogenicity of the disaccharide palatinose in experimental dental caries of rats,Infect. Immun. 39, 43–49 (1983).
Y. Tsuji, K. Yamada, N. Hosoya, and S. Moriuchi, Digestion and absorption of sugar and sugar substitutes in rat's small intestine,J. Nutr. Sci. Vitaminol. 32, 93–100 (1986).
J. Kashimura, Y. Nakajima, Y. Benno, K. Endo, and T. Mitsuoka, Effects of palatinos and its condensate intake on human fecal microflora,Bifidobacteria microflora.8, 45–50 (1989).
J. Kashimura, Y. Nakajima, Y. Benno, and T. Mitsuoka, Comparison of fecal microflora among subjects given palatinose and its condensates,Jpn. Soc. Nutr. Food. Sci. (in Japanese)43, 175–180 (1990).
J. Kashimura, M. Kimura, H. Kondo, K. Yokoi, K. Nishio, Y. Nakajima, and Y. Itokawa,Jpn. Soc. Nutr. Food. Sci. (in Japanese)43, 27 (1990).
R. K. Crane, and T. H. Wilson, In vitro method for the study of the rate intestinal absorption of sugars,J. Appl. Physiol. 12, 145 (1958).
T. Mitsuoka, Recent trends in research on intestinal flora,Bifidobacteria microflora.1, 3 (1982).
T. Goda, S. Takase, and N. Hosoya, Hydrolysis of α-d-glucopyranosyl-1,6-sorbitol and α-d-glucopyranosyl-1,6-mannitol by rat intestinal disaccharidases,J. Nutr. Sci. Vitaminol. 34, 131 (1988).
J. Kashimura, T. Hara, and Y. Nakajima, Effects of isomaltulose-based oligomers on the human intestinal environment,Jpn. Soc. Nutr. Food. Sci. (in Japanese)46, 117 (1993).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kashimura, J., Kimura, M. & Itokawa, Y. The effects of isomaltulose, isomalt, and isomaltulose-based oligomers on mineral absorption and retention. Biol Trace Elem Res 54, 239–250 (1996). https://doi.org/10.1007/BF02784435
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02784435