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CD43, a molecule with multiple functions

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Abstract

To initiate a specific immune response, lymphoid cells integrate a variety of signals generated through the orchestrated interaction of multiple cell surface molecules with their counter-receptors. As a result of the specific recognition of the antigen through antigenspecific receptors, and of the monitoring of their particular environment through the so-called coreceptor molecules, lymphoid cells go through elaborate processes of maturation and activation, contributing to the plasticity and sensitivity of immune response. CD43 is the major sialic acid rich protein on the surface of lymphocytes. However, the specific roles of this protein in different lymphoid cells under normal physiological conditions remain largely unknown. In this review we will mainly focus on the recent advances concerning the functions of this molecule as a coreceptor of different lymphoid cells as well as on the participation of this molecule in different pathologies.

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  1. Institute De Biotecnologia/ UNAM, Apartado Postal 510-3, 62250, Cuernavaca, Mor., Mexico

    Yvonne Rosenstein, Angelica Santana & Gustavo Pedraza-Alva

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  1. Yvonne Rosenstein
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Correspondence to Yvonne Rosenstein.

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Rosenstein, Y., Santana, A. & Pedraza-Alva, G. CD43, a molecule with multiple functions. Immunol Res 20, 89–99 (1999). https://doi.org/10.1007/BF02786465

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