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Thiol oxidation and reduction in MHC-restricted antigen processing and presentation

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Abstract

Major histocompatibility complex (MHC) class I molecules are assembled in the endoplasmic reticulum (ER) as a trimer of the class I heavy chain, Β2 microglobulin (Β2m), and a short peptide. Assembly occurs in a complex with additional noncovalently associated proteins, which include the thiol oxidoreductase, ERp57. This molecule facilitates the formation of the correct disulfide bonds in glycoproteins as they fold in the ER and may play a key role in assembling a stable MHC class I-peptide complex. In the endocytic pathway, reduction of protein disulfide bonds is important for the generation of MHC class II-peptide complexes. This process is catalyzed by a γ-interferon-inducible thiol reductase (GILT). The possible requirement for catalysis of disulfide bond formation in MHC class I-restricted antigen processing and the known requirement for disulfide bond reduction in MHC class II-restricted antigen processing present interesting examples of the adaptation of cellular “housekeeping” functions to facilitate immune responses.

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Authors and Affiliations

  1. Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, 06520-8011, New Haven, CT

    Peter Cresswell, Balasubramanian Arunachalam, Naveen Bangia, Tobias Dick, Gundo Diedrich, Eric Hughes & Maja Maric

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  1. Peter Cresswell
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  2. Balasubramanian Arunachalam
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Correspondence to Peter Cresswell.

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Cresswell, P., Arunachalam, B., Bangia, N. et al. Thiol oxidation and reduction in MHC-restricted antigen processing and presentation. Immunol Res 19, 191–200 (1999). https://doi.org/10.1007/BF02786487

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