Abstract
The MHC class II antigen processing pathway provides a mechanism to selectively present peptides generated in the endosomal compartments of antigen presenting cells to CD4+ T cells. Transport of newly synthesized class II molecules to the endosomal pathway requires the function of an accessory protein, invariant chain, which contains a region that interacts directly with the class II peptide binding site. Release of invariant chain and peptide loading by class II molecules are facilitated by a second accessory protein, HLA-DM. This MHC-encoded membrane protein catalyzes peptide exchange reactions, influencing the repertoire of peptides that are available for recognition by T cells.
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Jensen, P.E., Weber, D.A., Thayer, W.P. et al. HLA-DM and the MHC class II antigen presentation pathway. Immunol Res 20, 195–205 (1999). https://doi.org/10.1007/BF02790403
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DOI: https://doi.org/10.1007/BF02790403