Abstract
Keshan disease is an endemic cardiomyopathy of unknown cause in The People’s Republic of China that occurs most frequently in children under 15 years of age and women of child-bearing age. Studies of children 1–9 years old in Mianing County of Sichuan Province have indicated that Keshan disease is a selenium responsive condition. Incidence rates of 9.5–13.5/1000 in 1974–1975 were reduced to 1–2/1000 in children treated with a tablet weekly of 0.5–1 mg sodium selenite. During 1974–1977, only 21 cases of the disease occurred in 36,603 treated children, compared with 106 cases in 9430 untreated children, of whom 53 died and 5 still have insufficient heart function. Occurrence of the disease was invariably associated with a lower selenium content of cereals, and of hair (less than 0.12 ppm Se) in residents from affected, compared with non-affected, areas. The dose relationship between selenium and regional characteristics of Keshan disease suggests that it is probably a biogeochemical disease; other etiological factors have also been considered.
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References
Keshan Disease Research Department of Xian Medical College,Zhong Ji Yi Kan No. 1, p. 11 (1978) (in Chinese).
Keshan Disease Research Group of the Chinese Academy of Medical Sciences,Wei Sheng Yan Jiu 1 (2), 16 (1972) (in Chinese).
The Research Group of Keshan Disease of Chinese Academy of Medical Sciences,Wei Sheng Yan Jiu 6 (1), 47 (1977) (in Chinese).
The Research Group of Keshan Disease of Chinese Academy of Medical Sciences, Collected papers on Keshan Disease, No. 1, 39 (1977) (in Chinese).
The Research Group of Keshan Disease of Chinese Academy of Medical Sciences, National Symposium on the Etiology of Keshan Disease—Special Seminar on the Nutrients Deficiency in the Etiology of Keshan Disease (1976) (in Chinese, copies distributed among the participants).
The Research Group of Keshan Disease of Chinese Academy of Medical Sciences, Collected papers on Keshan Disease No. 1, 7 (1977) (in Chinese).
The Research Group of Keshan Disease of Chinese Academy of Medical Sciences, Collected papers on Keshan Disease No. 1, 57 (1977) (in Chinese).
The Research Group of Keshan Disease of Chinese Academy of Medical Sciences, Collected papers on Keshan Disease, No. 1, 53 (1977) (in Chinese).
The Research Group of Keshan Disease of Chinese Academy of Medical Sciences, Collected papers on Keshan Disease, No. 1, 48 (1977) (in Chinese).
M. Cummins, et al.,Anal. Chem. 37, 430 (1965).
J. H. Watkinson,Anal. Chem. 38, 92 (1966).
J. B. Wilkie, et al.J. Agr. Food Chem. 18, 945 (1970).
The Research Group of Keshan Disease of Chinese Academy of Medical Sciences, Collected papers on Keshan Disease, No. 1, 24 (1977) (in Chinese).
The Research Group of Keshan Disease of Chinese Academy of Medical Sciences, Collected papers on Keshan Disease, p. 12 (1977).
D. G. Hafeman, et al.J. Nutr. 104, 580 (1973).
The Research Group of Keshan Disease of Chinese Academy of Medical Sciences, National Symposium on the Etiology of Keshan Disease, p. 173 (1974) (in Chinese).
The Department of Keshan Disease of Xian Medical College, Literatures on Endemic Disease in Shanxi Province p. 89 (1975) (in Chinese).
The Geography Institute of Chinese Academy of Sciences, p. 4 (1976) (in Chinese).
WHO Technical Report Series No. 532, Geneva, 1973.
N. M. Griffiths, et al.New Zeal. Med. J. 80, 199 (1974).
C. M. Nekolaef, et al.,Pharmacol. Toxicol. 5, 571 (1976) (in Russian).
The Department of Keshan Disease of Jilin Medical College, National Symposium on the Etiology of Keshan Disease, 27 (1974) (in Chinese).
The Department of Keshan Disease of Harbin Medical College,J. Harbin Med. Coll. (Special Seiminar on the Nutrients Deficiency in the Etiology of Keshan Disease) No. 4, 93, (1974) (in Chinese).
The Department of Keshan Disease of Harbin Medical College,J. Harbin Med. Coll. (Special Symposium on Keshan Disease) (Suppl.) p. 100 (1976) (in Chinese).
K. Schwarz, et al.J. Am. Chem. Soc. 79, 3292 (1957).
J. N. Thompson, et al.J. Nutr. 97, 335 (1969).
J. T. Rotruck et al.,Science 179, 588 (1973).
L. Flohe,Fed. Eur. Biochem. Soc. Lett. 32, 132 (1973).
K. Schwarz,Fed. Proc. 20, 266 (1961).
L. L. Hopkins, Jr. et al., “Selenium in Biomedicine,” O. H. Muth, J. E. Oldfield and P. H. Weswing (eds)., AVI Publishing Co., 1969 p. 215.
D. E. L. Money,New Zeal. Med. J. 71, 32 (1970).
R. J. Shamberger, Proceedings of the Symposium on Selenium and Tellurium in the Environment, Industrial Health Foundation, Pittsburgh, 1976, p. 253.
G. N. Schrauzer, Ibid. Proceedings of the Symposium on Selenium and Tellurium in the Environment, Industrial Health Foundation, Pittsburgh, 1976, p. 293.
R. D. H. Stewart, et al.Brit. J. Nutr. 40, 45 (1978).
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Chen, X., Yang, G., Chen, J. et al. Studies on the relations of selenium and Keshan disease. Biol Trace Elem Res 2, 91–107 (1980). https://doi.org/10.1007/BF02798589
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DOI: https://doi.org/10.1007/BF02798589