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Effect of diallyl disulfide on the hepatic glutathione s-transferase activity in rat: Diallyl disulfide effect on the glutathione S-transferase

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Abstract

Glutathione s-transferase is thought to play a key role in initiating the detoxication of potential alkylating agents, including pharmacologically active compounds. It is widely accepted that garlic contains allin which is converted to allicin by alliinase. Allicin is easily degraded to diallyl disulfide and other components. This report attempted to observe the effect of diallyl disulfide on some biological activities.

It was observed that the activity of serum transaminase was not changed by the treatment of diallyl disulfide. The liver cytosolic glutathione s-transferase was significantly increased. whereas the microsomal glutathione s-transferase was not increased.

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Authors and Affiliations

  1. Dept. of Pharmacology, College of Pharmacy, Yeungnam University, 632, Gyongsan, Korea

    Keun Huh, Sang-Il Lee & Jong-Min Park

  2. Dept. of Food and Nutrition, Dong-A University, 600-02, Pusan, Korea

    Seok-Hwan Kim

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  1. Keun Huh
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  2. Sang-Il Lee
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  3. Jong-Min Park
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Huh, K., Lee, SI., Park, JM. et al. Effect of diallyl disulfide on the hepatic glutathione s-transferase activity in rat: Diallyl disulfide effect on the glutathione S-transferase. Arch. Pharm. Res. 9, 205–209 (1986). https://doi.org/10.1007/BF02856632

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  • DOI: https://doi.org/10.1007/BF02856632

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