Abstract
Lack of effective cooperation among researchers in the applicable biological, physical, and clinical sciences has accounted, in large measure, for the lack of successful development in the United States of any significant number of new plant drugs during the latter part of the 20th century. Unrealistic federal regulations that tend to render unprofitable such research have also played an important role in hindering the development of new plant drugs. It is likely that both of these factors will change in the future as health-conscious consumers demand more accurate information and wider availability of natural drug products. Several anticipated developments will greatly facilitate research and production in this previously difficult area. These include the development of new, simplified bioassay procedures; improved, easily applied analytical methods; and innovative plant-cell-culture methodologies, possibly involving genetic manipulation. The kinds of drugs that need to be developed using such techniques are discussed. It is concluded that significant new plant drugs and new methods of producing them will be developed to serve mankind during the 21st century.
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Literature Cited
Anonymous. 1982. Blitzumfrage ergab: Kräutertees immer beliebter. Deutsche Apotheker-Zeitung 122(43): xv.
Anonymous. 1985. The milk thistles. Lawrence Rev. 6: 1–3.
Baerheim Svendsen, A. 1984. Biogene Arzneistoffe—heute noch oder heute wieder?In F.-C. Czygan, ed, Biogene Arzneistoffe, p. 27–44. Friedr. Vieweg & Sohn, Braunschweig/Wiesbaden.
Barz, W., and B. E. Ellis. 1981. Potential of plant cell cultures for pharmaceutical production.In J. L. Beal and E. Reinhard, ed, Natural Products as Medicinal Agents, p. 471–507. Hippokrates Verlag, Stuttgart.
Brodie, D. C., and W. E. Smith. 1985. Implications of new technology for pharmacy education and practice. Amer. J. Hosp. Pharm. 42: 81–95.
Cooks, R. G., R. W. Kondrat, M. Youssefi, and J. L. McLaughlin. 1981. Mass-analyzed ion kinetic energy (MIKE) spectrometry and the direct analysis of coca. J. Ethnopharmacol. 3: 299–312.
Dragendorff, G. 1884. Plant Analysis: Qualitative and Quantitative, p. 8–98. Baillère, Tindall, and Cox, London.
Farnsworth, N. R. 1979. The present and future of pharmacognosy. Amer. J. Pharm. Educ. 43: 239–243.
— 1984. The role of medicinal plants in drug development.In P. Krogsgaard-Larsen, S. Brøgger Christensen, and H. Kofod, ed, Natural Products and Drug Development, p. 17–30. Munksgaard, Copenhagen.
Ferrigni, N. R., J. E. Putnam, B. Anderson, L. B. Jacobsen, D. E. Nichols, D. S. Moore, J. L. McLaughlin, R. G. Powell, and C. R. Smith, Jr. 1982. Modification and evaluation of the potato disc assay and antitumor screening of Euphorbiaceae seeds. J. Nat. Prod. 45: 679–686.
Fijita, Y., M. Tabata, A. Nishi, and Y. Yamada. 1982. New medium and production of secondary compounds with the two-staged culture method.In A. Fujiwara, ed, Plant Tissue Culture 1982, p. 399–400. Japanese Assoc. for Plant Tissue Culture, Tokyo.
Furuya, T., T. Yoshikawa, and M. Taira. 1984. Biotransformation of codeinone to codeine by immobilized cells ofPapaver somniferum. Phytochemistry 23: 999–1001.
Galsky, A. G., J. P. Wilsey, and R. G. Powell. 1980. Crown gall tumor disc bioassay: a possible aid in the detection of compounds with antitumor activity. Pl. Physiol. 65: 184–185.
Heinstein, P. F. 1985. Future approaches to the formation of secondary natural products in plant cell suspension cultures. J. Nat. Prod. 48: 1–9.
Hikino, H. 1984. Antihepatotoxic principles in oriental medicinal plants.In P. Krogsgaard-Larsen, S. Brøgger Christensen, and H. Kofod, ed, Natural Products and Drug Development, p. 374–390. Munksgaard, Copenhagen.
Malone, M. H., and R. C. Robichaud. 1962. A Hippocratic screen for pure or crude drug materials. Lloydia 25: 320–332.
Marconi, R. D. 1983. Let’s Grow Younger, p. 9–10. Scientific Nutrition Press, Seal Beach, CA.
McChesney, J. D., and R. P. Adams. 1985. Co-evaluation of plant extracts as petrochemical substitutes and for biologically active compounds. Econ. Bot. 39: 74–86.
Meyer, B. N., N. R. Ferrigni, J. E. Putnam, L. B. Jacobsen, D. E. Nichols, and J. L. McLaughlin. 1982. Brine shrimp: a convenient general bioassay for active plant constituents. Pl. Med. 45: 31–34.
Trotter, R. T., II, M. H. Logan, J. M. Rocha, and J. L. Boneta. 1983. Ethnography and bioassay: combined methods for a preliminary screen of home remedies for potential pharmacological activity. J. Ethnopharmacol. 8: 113–119.
Tyler, V. E. 1979. Plight of plant-drug research in the United States today. Econ. Bot. 33: 377–383.
— 1984. Perspective on herbal medicine. Nutr. Forum 1:11.
-. In press. Some recent advances in herbal medicines. Pharm. Int.
Wagner, H. 1984. Immunostimulants of fungi and higher plants.In P. Krogsgaard-Larsen, S. Brøgger Christensen, and H. Kofod, ed, Natural Products and Drug Development, p. 391–404. Munksgaard, Copenhagen.
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Presented at the Symposium on Economic Botany in the Year 2000, Twenty-sixth Annual Meeting, Society for Economic Botany, University of Florida, Gainesville, FL, 13 August 1985; symposium organized and chaired by Drs. W. Hardy Eshbaugh and H. Garrison Wilkes.
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Tyler, V.E. Plant drugs in the twenty-first century. Econ Bot 40, 279–288 (1986). https://doi.org/10.1007/BF02858985
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DOI: https://doi.org/10.1007/BF02858985