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Ramihyphins—Antifungal and morphogenic antibiotics fromFusarium sp. S-435

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Abstract

Fusarium sp. S-435 produces a group of related antifungal antibiotics. Three components of a mixture were isolated in a pure state from the mycelium and cultivation medium of the productive strain: ramihyphins A, B and C. Another two components (D and E) were demonstrated by thin-layer chromatography. Ramihyphin A is the main component of the mixture. Its basic physical and chemical properties are presented. The antibiotic is not active against bacteria, yeast-like microorganisms, oomycetes and several protozoa. It inhibits the growth of higher filamentous fungi, stimulating ramification of hyphae when used at subfungistatic concentration. Ramihyphin A does not inhibit germination of conidia of sensitive fungi but stops their growth after their germination.Blastomyces dermatitidis, Coccidioides immitis andHistoplasma capsulatum belong to most sensitive pathogenic fungiin vitro. Ramihyphin A inhibits considerably the growth of the following phytopathogenic fungi:Stereum hirsutum, Neurospora sitophila, Botrytis cinerea, Monilia fructigena andAlternaria tenuis. The antibiotic exhibits antifungal effects alsoin vivo and is relatively little toxic for HeLa cells.

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Authors and Affiliations

  1. Department of General Biology, Biological Institute, Slovak Academy of Sciences, 885 34, Bratislava

    Z. Baráth

  2. Department of Technical Microbiology and Biochemistry, Faculty of Chemistry, Slovak Polytechnical University, 880 37, Bratislava

    H. Baráthová, V. Betina & P. Nemec

Authors
  1. Z. Baráth
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  2. H. Baráthová
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  3. V. Betina
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  4. P. Nemec
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Baráth, Z., Baráthová, H., Betina, V. et al. Ramihyphins—Antifungal and morphogenic antibiotics fromFusarium sp. S-435. Folia Microbiol 19, 507–511 (1974). https://doi.org/10.1007/BF02872917

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  • DOI: https://doi.org/10.1007/BF02872917

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