Abstract
Eurotium repens mycelium cultivated under static conditions was used to isolate and identify metabolities—echinulin, physcion, erythroglaucin, flavoglaucin and asperentin; the filtrate of the culture yielded asperentin 8-methylether. The broadest biological activity spectrum was displayed by asperentin which had antibacterial and antifungal effects and, at a concentration of 86 ώg/ml, caused 50 % mor7 tality inArtemia saline larvae. The highest cytotoxicity towards HeLa cells was found in physcion which caused 50 % growth inhibition at a concentration of 0.1 ώg/ml.
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Podojil, M., Sedmera, P., Vokoun, J. et al. Eurotium (Aspergillus) repens metabolites and their biological activity. Folia Microbiol 23, 438–443 (1978). https://doi.org/10.1007/BF02885572
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DOI: https://doi.org/10.1007/BF02885572