Abstract
Lipid peroxidation and hemolysis in humand red blood cells (RBCs) increased on their exposure to increasing concentrations of lead acetate (0.01–1.0mM). However pretreatment of RBCs with ascorbic acid (2mM and 4mM) significantly reduced the effect of lead acetate on lipid peroxidation and hemolysis in human RBCs.
References
Hammond, P.B. (1977). Ann. Rev. Pharmacol. Toxicol. 17, 197–214.
Ganther, H. (1980). Ann. N.Y. Acad. Sci. U.S.A. 355, 212.
Reddy, R.C., Scholz, R.W. and Massaro, E.J. (1981). Toxicol. Appl. Pharmacol. 61, 460.
Sree Kumar, K., Rowse, C. and Hochstein, P. (1978). Biochem. Biophys. Res. Commun. 83, 587–592.
Chiu, D., Lubin, B. and Shohet, S.B. (1982) in Free Radicals in Biology (Pryor, W. ed.) Vol. 5 pp 115–160, Academic, San Diego.
Chiu, D., Kuypers, F. and Lubin, B. (1989). Seminars in Hematol. 26, 257–267.
Clemens, M.R. and Waller, H.D. (1987). Chem. Phys. Lipids 45, 251–268.
Drabkin, D.L. and Austin, J.A. (1935). J. Biol. Chem. 112, 51–57.
Stocks, J. and Dormandy, T.L. (1971). Br. J. Hematol, 20, 95–110.
Horwitt, M.K., Harvey, C.C., Duncan, G.D. and Wilson, W.C. (1956). Am. J. Clin. Nutr., 4, 409–419.
Tappel, A.L. (1962). Vitam. Horm, 20, 493–501.
Tappel, A.L., Brown, W.D., Zodkin, H. and Maler, V.P. (1961). J. Am. Oll Chem. Soc 38, 5–9.
Packer, J.E., Slater, T.F. and Wilson, R.L. (1979). Nature 278, 733–738.
Tappel, A.L. (1968). Geriatrics 23, 97–105.
Ratty, A.K. and Das, N.P. (1986). IRCS Med. Sci. 14, 815–816.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Soni, G.L., Bansal, A.K. & Malhotra, N. Role of ascorbic acid in lead acetate induced lipid peroxidation and hemolysis in human RBC. Indian J Clin Biochem 7, 196–198 (1992). https://doi.org/10.1007/BF02886678
Issue Date:
DOI: https://doi.org/10.1007/BF02886678