Skip to main content
SpringerLink
Log in

Undifferentiated mononuclear cell in human embryonic liver; presumptive hematopoietic stem cell

  • Published:
Virchows Archiv B

Summary

An electron microscopic investigation of human embryonic liver revealed the existence of undifferentiated mononuclear cells in the earliest stages of hepatic hematopoiesis. They were too immature to be classified as precursors of various hematopoietic series and were considered presumptively as hematopoietic stem cells. These cells were found exclusively in the intercellular spaces of hepatocytes and were thought to be derived from septum transversum.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature

  • Bekkum, D. W. van, Noord, M. J. van, Maat, B., Dicke, K. A.: Attempts at identification of hemopoietic stem cell in mouse. Blood38, 547–558 (1971)

    PubMed  Google Scholar 

  • Dunn, C. D. R.: The differentiation of haemopoietic stem cells. Series Haematol.4, 41–71 (1971)

    Google Scholar 

  • Fukuda, T.: Fetal hemopoiesis. I. Electron microscopic studies of human yolk sac hemopoiesis. Virchows Arch. Abt. B (in press)

  • Grasso, J. A., Swift, H., Ackerman, G. A.: Observations on the development of erythrocytes in mammalian fetal liver. J. Cell Biol.14, 235–254 (1962)

    Article  PubMed  CAS  Google Scholar 

  • Kay, H. E. M., Playfair, J. H. L., Wolfendale, M., Hopper, P. K.: Development of the thymus in the human foetus and its relation to immunological potential. Nature (Lond.)196, 238–240 (1962)

    Article  CAS  Google Scholar 

  • Krantz, S. B., Jacobson, L. O.: Erythropoietin and the regulation of erythropoiesis. ChicagoLondon: Chicago University Press 1970

    Google Scholar 

  • Metcalf, D., Moore, M. A. S.: Haemopoietic cells. Amsterdam-London: North-Holland 1971

    Google Scholar 

  • Rifkind, R. A., Chui, D., Epier, H.: An ultrastructural study of early morphogenetic events during the establishment of fetal hepatic erythropoiesis. J. Cell Biol.40, 343–365 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Seki, M.: Differentiation of hematopoietic cell (Jap.), Handbook of cytology. 7. (Ogawa, K., Oda, T., Kurosumi, K., Sugino, S. eds.), p. 185–219. Tokyo: Asakura, 1971

    Google Scholar 

  • Streeter, G. L.: Developmental horizons in human embryos. Description of age group XI, 13 to 20 somites, and age group XII, 21 to 29 somites. Contr. Embryol. Carneg. Instn30, 211–245 (1942)

    Google Scholar 

  • Streeter, G. L.: Developmental horizons in human embryos. Description of age group XIII, embryos about 4 to 5 millimeters long, and age group XIV, period of indentation of the lens vesicle. Contr. Embryol. Carneg. Instn31, 27–63 (1945)

    Google Scholar 

  • Streeter, G. L.: Developmental horizons in human embryos. Description of age group XV, XVI, XVII, and XVIII. Contr. Embryol. Carneg. Instn32, 133–203 (1948)

    Google Scholar 

  • Streeter, G. L.: Developmental horizons in human embryos. Description of age group XIX, XX, XXI, XXII, and XXIII. Contr. Embryol. Carneg. Instn34, 165–196 (1951)

    Google Scholar 

  • Töndury, G., Kubik, S.: Zur Ontogenese des lymphatischen Systems. In: Handbuch der allgemeinen Pathologie, Bd. III/6, Lymphgefässystem (Meesen, H., Hrsg.) Berlin-Heidelberg-New York: Springer 1972

    Google Scholar 

  • Zamboni, L.: Electron microscopic studies of blood embryogenesis in humans. 2. The hematopoietic activity in the fetal liver. J. Ultrastruct. Res.12, 525–541 (1965)

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Tohoku University, School of Medicine, Japan

    T. Fukuda

  2. Institute of Pathological Anatomy, University of Zürich, CH-8006, Kantonsspital, Schmelzbergstraße 12, Zürich, Switzerland

    T. Fukuda

Authors
  1. T. Fukuda
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fukuda, T. Undifferentiated mononuclear cell in human embryonic liver; presumptive hematopoietic stem cell. Virchows Arch. Abt. B Zellpath. 14, 31–34 (1973). https://doi.org/10.1007/BF02889171

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02889171

Keywords

Search

Navigation