Zusammenfassung
In Epithelkörperadenomen von zwei Patienten mit den Symptomen des Hyperparathyreoidismus wurden Membransysteme nach Art der Annulatae lamellae nachgewiesen. Die Tumoren bestanden vorwiegend aus Hauptzellen mit den Zeichen unterschiedlicher Aktivität sowie einigen oxyphilen Zellen. Annulatae lamellae kommen häufig in Hauptzellen an beliebiger Stelle innerhalb des Cytoplasmas und hier auch in unmittelbarer Nachbarschaft der Kernhülle vor. Die Annulatae lamellae wechseln in Konfiguration und Ausdehnung. Sie bestehen aus parallel angeordneten Membranpaaren, die gestreckt, bogenförmig, halbkreisoder kreisförmig angeordnet sind. Die hellen Spalträume zwischen den Lamellen stehen häufig in kontinuierlicher Verbindung mit den rauhen endoplasmatischen Reticulum. Mitochondrien finden sich in erweiterten Abschnitten zwischen den Membranpaaren. Es wird erwogen, daß die enge räumliche Beziehung zwischen Annulatae lamellae und Mitochondrien Ausdruck eines funktionellen Zusammenhanges zwischen diesen beiden Zellkomponenten ist.
Summary
Membrane system interpreted as annulate lamellae are found in one parathyroid adenoma from each of two patients with symptoms of hyperparathyroidism. The tumors are light and electron microscopically composed of chief cells with structural signs of varying activity, and rather few oxyphil cells. Annulate lamellae are frequently seen in the chief cells in any portion of the cytoplasm. Sometimes they are very close to the nuclear envelope. The configuration and size of the annulate lamellae vary. They are composed of parallel arrays of double membranes in straight, curved, semi-circular or circular arrangement. The membranes are smooth-surfaced and merge at intervals to form pores. The lamellae are often separated by or surrounded by electron lucent spaces that are continuous with granular endoplasmic reticulum. Mitochondria occur in dilated portions between the double membranes constituting each lamella. Although the close spatial relationship between annulate lamellae and mitochondria may be of coincidental nature, it is believed that the association between these two cellular components is of functional significance.
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Boquist, L. Annulate lamellae in human parathyroid adenoma. Virchows Arch. Abt. B Zellpath. 6, 234–246 (1970). https://doi.org/10.1007/BF02899126
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DOI: https://doi.org/10.1007/BF02899126