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Epidermal cell proliferation during the first 24 hr after injection of an aqueous skin extract (Chalone)

Zellproliferation der Epidermis während der ersten 24 Std nach Gabe eines wäßrigen Hautextraktes

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Virchows Archiv B

Zusammenfassung

Nach einer einzelnen intraperitonealen Injektion aus 5 mg lyophiliziertem Hautpulver („Chalone“) wurde die epidermale Mitoserate für ungefähr 4 Std gehemmt. Diese Periode wurde nicht von einer kompensatorischen Steigerung der Mitoserate gefolgt. Die Resultate weisen darauf hin, daß die Hemmung der Mitoserate von einer vorübergehenden Arretierung in der G2-Phase herrührt und daß einige Zellen ständig in der G2-Phase verbleiben.

Summary

After a single intraperitoneal injection of 5 mg of lyophilized skin powder (“chalone”), the epidermal mitotic rate in hairless mice was depressed for about 4 hr. The period of decreased mitotic rate was not followed by an increased mitotic rate in the subsequent 22 hr. The results suggested that the depression of the mitotic rate could be caused by a delay of cells in G2, and that some of the affected cells in G2 were permanently prevented from continuing their division.

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Authors and Affiliations

  1. Institute of General and Experimental Pathology, Rikshospitalet, Oslo, Norway

    K. Elgjo

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Elgjo, K. Epidermal cell proliferation during the first 24 hr after injection of an aqueous skin extract (Chalone). Virchows Arch. Abt. B Zellpath. 4, 119–125 (1969). https://doi.org/10.1007/BF02906066

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  • DOI: https://doi.org/10.1007/BF02906066

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