Abstract
Somatic cell hybrids between cells of widely divergent mammalian species display a range of chromosomal and genetic anomalies which may be the equivalent of the “genomic shock” phenomena observed in many plant and animal interspecific hybrids. Mouse-kangaroo hybrids show extreme segregation and fragmentation of the kangaroo chromosomes. Here 1 show that, in addition to the chromosomal instability, some hybrids display unstable expression of three genes borne on the kangaroo active maternal X chromosome. These genes (HPRT, G6PD andPGK) may be co-ordinately inactivated at high frequency, then reactivated once more. I suggest that this reversible inactivation in interspecific hybrids may be the result of an unstable change at an X inactivation centre located in the kangaroo Xq.
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Marshall Graves, J.A. Genome instability in interspecific cell hybrids I. Unstable expression of genes in divergent cell hybrids. J. Genet. 67, 9–22 (1988). https://doi.org/10.1007/BF02927733
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DOI: https://doi.org/10.1007/BF02927733