Abstract
Background
Radiation therapy after breast-conserving surgery (BCS) reduces the risk of local recurrence. However, whether radiation therapy is necessary for all patients undergoing BCS remains unclear.
Methods
In order to determine the selection criteria for patients who can safely omit radiation therapy and to confirm the survival benefit of quadrantectomy without radiation therapy, we reviewed 107 patients who underwent quadrantectomy without radiation therapy between February 1988 and July 1995.
Results
The 5-year overall survival, disease-free survival and cumulative local recurrence rates were 93.7%, 80.7% and 12.1% respectively. There were no significant differences of 5-year overall survival (94.0% vs 94.1%) and disease-free survival rates (83.1% vs 70.0%) between patients with or without tamoxifen. The 5-year cumulative local recurrence rate of patients with tamoxifen, however, tended to be lower (p=0.0810) than that of patients without tamoxifen. The 5-year cumulative local recurrence rate of the patients aged 45 or less was significantly higher than that of patients aged from 45 to 55 years and those over 55 (p=0.0090 and 0.0089, respectively). In ER positive patients, the 5-year cumulative local recurrence rate of patients with tamoxifen tended to be lower (p=0.0791) than that of patients without tamoxifen.
Conclusion
The survival rate of quadrantectomy without radiation therapy was acceptable. While the risk of local recurrence following quadrantectomy without radiation therapy is substantial, radiation therapy following quadrantectomy might not be necessary in elderly ER positive women receiving adjuvant tamoxifen therapy.
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Abbreviations
- BCS:
-
Breast-conserving surgery
- RT:
-
Radiation therapy
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Shin, E., Takatsuka, Y., Okamura, Y. et al. A retrospective study of breast cancer patients treated with quadrantectomy without radiation therapy. Breast Cancer 6, 109–116 (1999). https://doi.org/10.1007/BF02966916
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DOI: https://doi.org/10.1007/BF02966916