Abstract
Repeated column chromatographic separation of the CH2Cl2 extract ofArtemisia stolonifera (Asteraceae) led to the isolation of a triterpene (I), a sesquiterpene (II), two aromatic compounds (III andIV) and a benzoquinone (V). Their structures were determined by spectroscopic means to be simiarenol (I), (1S,7S)-1β-hydroxygermacra-4(15),5, 10(14)-triene (II), 3′-methoxy-4′-hydroxy-trans-cinnamaldehyde (III), vanillin (IV) and 2,6-dimethoxy-1,4-benzoquinone (V), respectively. Among these products, compoundV showed significant cytotoxicity against five human tumor cell linesin vitro, A549 (non small cell lung adenocarcinoma), SK-OV-3 (ovarian), SK-MEL-2 (skin melanoma), XF498 (CNS) and HCT15 (colon) with ED50 values ranging from 1.33~4.22 βg/ml.
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Kwon, H.C., Choi, S.U. & Lee, K.R. Phytochemical constituents ofArtemisia stolonifera . Arch Pharm Res 24, 312–315 (2001). https://doi.org/10.1007/BF02975098
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DOI: https://doi.org/10.1007/BF02975098