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The reaction of Digitoxin and Digoxin with cyanoacetic acid hydrazide: Synthesis of Coumarin, Thiazole, Thiophene and Pyridine derivatives with potential biological activities

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Abstract

The reaction of either Digitoxin or Digoxin with cyanoacetic acid hydrazide gave the hydrazone derivatives3a and3b respectively. The reactivity of the latter products towards chemical reagents was studied to give heterocyclic derivatives with potential biological activities.

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Authors and Affiliations

  1. Hormones Department, National Research Center, Dokki, Ciza, Egypt

    Senot H. Doss & Nadia A. Louca

  2. National Organization for Drug Control & Research, P.O. 29, Cairo, Egypt

    Wagnat W. Wardakhan

Authors
  1. Senot H. Doss
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  2. Wagnat W. Wardakhan
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  3. Nadia A. Louca
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Correspondence to Senot H. Doss.

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Doss, S.H., Wardakhan, W.W. & Louca, N.A. The reaction of Digitoxin and Digoxin with cyanoacetic acid hydrazide: Synthesis of Coumarin, Thiazole, Thiophene and Pyridine derivatives with potential biological activities. Arch Pharm Res 24, 377–384 (2001). https://doi.org/10.1007/BF02975179

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  • DOI: https://doi.org/10.1007/BF02975179

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