Abstract
The essential oils fromCedrus atlantica, Styrax tonkinensis, Juniperus communis, Lavandula angustifolia, Melaleuca alternifolia, Pelargonium graveolens, Pogestemon patchouli andRosmarinus officinalis were analyzed by GC-MS. Antifungal activities of the oils were investigated by disk diffusion assay and the broth dilution method againstAspergillus niger andA. flavus. The effects of geraniol and the essential oil fraction fromP. graveolens on the antifungal activity of amphotericin B and ketoconazole were examined using a checkerboard microtiter assay against bothAspergillus fungi. Most of the tested essential oils, with the exception ofC. atlantica, J. communis, and P. patchouli, significantly inhibited growth ofA. niger and to a lesser extent that ofA. flavus, with MICs (minimal inhibitory concentrations) in the range 0.78-12.5 mg/mL The essential oil fraction ofP. graveolens and its main components, geraniol and citronellol, exhibited additive effects with amphotericin B and with ketoconazole against bothAspergillus species, resulting in fractional inhibitory concentration (FIC) indices ranging from 0.52 to 1.00.
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Shin, S. Anti-Aspergillus activities of plant essential oils and their combination effects with ketoconazole or amphotericin b. Arch Pharm Res 26, 389–393 (2003). https://doi.org/10.1007/BF02976696
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DOI: https://doi.org/10.1007/BF02976696