Summary
The mode of inheritance of serum cholesterol level and its relationship to body weight in white mice was considered:
-
1.
It was found that in male mice the serum cholesterol was highly heritable but not in female.
-
2.
Weight at 63 days was highly heritable in the case of the males and not in the females.
-
3.
There was a high genetic correlation between cholesterol level and weight in male mice and to a considerably less degree in female. The trend is similar in phenotypic correlation.
-
4.
It is suggested that the low incidence of atherosclerosis in women could be due to differences in the mode of inheritance of cholesterol level in two sexes.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Boas, E. P., Parets, A. D. And Adlersberg, D. (1948). Hereditary disturbance of cholesterol metabolism. A factor in the genesis of atherosclerosis. InAtherosclerosis. Mechanism as a Guide to Preventions. Lea and Febiger: Philadelphia.
Bruell, J. H. (1963). Additive inheritance of serum cholesterol level in mice.Science,142, 1664–1666.
Cherms, F. L. (Jr.),Wilcox, F. H. And Shaffner, C. S. (1960). Genetic studies of serum cholesterol level in the chicken.Poultry Sci.,39, 889–892.
Dadlani, H. V. And Prabhu, S. S. (1971). Quantitative genetic studies in the mouse (Mus musculus L.). III. Body weightJ. Genet.,60, 214–221.
Dickerson, G. E. (1959), Techniques for research in quantitative animal genetics. InTechniques and Procedures in Animal Production Research. American Society of Animal Production.
Epstein, F. H., Block, B. D., Hand, E. A. And Francis, T. J. (1959). Familial hypercholesterolemia xanthomatosis and coronary heart disease. InAtherosclerosis. Mechanism as a Guide to Prevention. Lea and Febiger: Philadelphia.
Falconer, D. S. (1953). Selection for large and small size in mice.J. Genetics,51, 470–501.
Hardy, L. B., Anger, H. V. And Wilcox, F. H. (1962). Studies on the underlying mechanism for differences in serum cholesterol.Amer. J. Physio.,202, 997–1001.
Heftmann, E. And Mosettig, E. (1960).Biochemistry of Steroids. Reinhold Publishing Corporation: New York.
Kempthorne, O. (1957).An Introduction to Genetic Statistics. John Wiley and Sons: New York.
Macarthur, J. W. (1949). Selection for small and large body size in the house mouse.Genetics,34, 194–209.
Pick, R., Stamler, J., Rodband, S. And Katz, L. (1952). Estrogen induced regression of coronary atherosclerosis in cholesterol fed chicks. InHormones and Atherosclerosis. Academic Press: New York.
Stamler, J., Pick, R., Kalz, L. N., Pick, A. And Kaplan, B. M. (1959). InHormones and Atherosclerosis. Academic Press: New York.
Strecher, R. M. And Hersh, A. H. (1949). Note on genetics of hypereholesterolemia.Science.109, 61–63.
Wilcox, F. H., Gherms, F. L. (Jr.),Van Yleck, L. D., Harvey, W. R. And Shaffner, C. S. (1963). Estimates of genetic parameters of serum cholesterol level.Poultry Sci.,42, 37–42.
Wilcox, F. H. And Shaffner, C. S. (1963). Performance of lines selected for high and low serum cholesterol level.Poultry Sci.,42, 1033–1035.
Wootton, I.D.P. (1964).Micro-analysis in Medical Biochemistry. J. & A. Churchill Ltd.: London.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Eapen, K.J., Goswami, O.B. & Pillai, S.K. Inheritance of serum cholesterol and its relation to body weight in white mice. J Genet 60, 222–229 (1971). https://doi.org/10.1007/BF02984164
Issue Date:
DOI: https://doi.org/10.1007/BF02984164