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Copper supplementation effects on indicators of copper status and serum cholesterol in adult males

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Abstract

Two 6-wk double-blind studies evaluated the effects of supplements of 2 or 3 mg Cu/d on serum copper, ceruloplasmin, red-blood-cell super oxide dismutase (RBC-SOD), total serum cholesterol, and serum lipoprotein-cholesterol fractions in adult males. Study I had 6 supplemented and 8 placebo subjects, whereas study II had 7 and 6, respectively. Copper supplementation did not appear to affect serum copper levels, RBC-SOD, hematocrit, and ceruloplasmin levels when assayed by radial immunoassay diffusion. Supplementation with 2 mg Cu/d produced an increase in LDL cholesterol and the percentage of cholesterol as LDL at wk 4 compared to the placebo group, and a concomitant decline in VLDL-cholesterol levels and the percentage of cholesterol as VLDL. At wk 6, the percentage of cholesterol as LDL increased and that of cholesterol as VLDL decreased compared to baseline values in the supplemented group. Supplements of 3 mg Cu/d increased hemoglobin levels ceruloplasmin activity, and serum total-cholesterol levels at wk 6 compared to placebos. Differences in cholesterol may be partly explained by variability in the placebo groups in both studies. Copper supplementation effects on cholesterol deserves further investigation.

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Author notes

  1. Denis M. Medeiros

    Present address: Department of Human Nutrition and Food Management, The Ohio State University, 265 Campbell Hall, 1787 Neil Avenue, 43210-1295, Columbus, OH

Authors and Affiliations

  1. Department of Home Economics, The University of Wyoming, 82071, Laramie, WY

    Denis M. Medeiros, Ann Milton & Lucy Stacy

  2. School of Pharmacy, The University of Wyoming, 82071, Laramie, WY

    Emery Brunett

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  1. Denis M. Medeiros
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  2. Ann Milton
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  3. Emery Brunett
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  4. Lucy Stacy
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Medeiros, D.M., Milton, A., Brunett, E. et al. Copper supplementation effects on indicators of copper status and serum cholesterol in adult males. Biol Trace Elem Res 30, 19–35 (1991). https://doi.org/10.1007/BF02990339

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  • DOI: https://doi.org/10.1007/BF02990339

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