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Bone Marrow Colony-Forming Unit Assay in Cats With Naturally Occurring Myelodysplastic Syndromes

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Abstract

Feline myelodysplastic syndromes (MDS) has been diagnosed in many cats infected with feline leukemia virus, although the pathogenesis of this hematopoietic deficiency has been unclear. In this study, we assayed the bone marrow erythroid colony-forming units (CFU-E) and granulocyte-machrophage CFUs (CFU-GM) to investigate the pathogenesis of feline MDS. The number of CFU-E colonies was decreased in 4 of 7 cats with MDS, and the number of CFU-GM colonies was also decreased in 4 cats. Furthermore, small colonies of CFU-GM were found in all 7 cases. These findings indicated that refractory cytopenia of feline MDS could be caused by abnormal maturation and differentiation of hematopoietic stem cells in bone marrow, as it is in human MDS. The pathogenesis of feline MDS might be similar to that of human MDS.

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Authors and Affiliations

  1. Department of Pathobiology, School of Veterinary Medicine, Nihon University, Kanagawa

    Naho Nagashima, Rui Kano & Atsuhiko Hasegawa

  2. Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Azabu University, Kanagawa

    Masaharu Hisasue

  3. Department of Laboratory Medicine, Faculty of Medicine, University of Tokyo, Tokyo

    Katsumi Higashi

  4. Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan

    Hajime Tsujimoto

Authors
  1. Naho Nagashima
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  2. Masaharu Hisasue
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  3. Katsumi Higashi
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  4. Rui Kano
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  5. Hajime Tsujimoto
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  6. Atsuhiko Hasegawa
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Corresponding author

Correspondence to Rui Kano.

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Nagashima, N., Hisasue, M., Higashi, K. et al. Bone Marrow Colony-Forming Unit Assay in Cats With Naturally Occurring Myelodysplastic Syndromes. Int J Hematol 73, 453–456 (2001). https://doi.org/10.1007/BF02994006

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  • DOI: https://doi.org/10.1007/BF02994006

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