Conclusion and Summary
The effect of preanaesthetic medication, methoxyflurane anaesthesia, and surgery on free hydrocortisone (= 17-OHCS) concentrations in plasma were studied in eleven patients. The preanaesthetic medication significantly decreased plasma levels of free 17-OHCS, but the changes in concentration were variable after methoxyflurane anaesthesia for 30 minutes. Surgical stress evoked significant elevation of free 17-OHCS levels in plasma. These findings would imply that methoxyflurane anaesthesia is not a stressing agent for the adrenal cortex in man.
RéSUMé
Nous avons étudié, chez onze malades, l’effet sur l’iydrocortisone libre ( = 17-OHCS) dans le plasma produit par la prémédication anesthésique, par l’anesthésie au méthoxyflurane et par la chirurgie. La prémédication anesthésique a abaissé de façon marquée les taux dans le plasma des 17-hydroxycorticostéroëdes, mais, après une anesthésie de trente minutes au méthoxyflurane, les changements ont été variables. L’agression chirurgicale a produit une élévation importante des taux dans le plasma des 17-hydroxycorticostéroides. Ces reésultats permettent de supposer que l’anesthésie au méthoxyflurane n’exercerait pas une agression sur le cortex surrénalien de Thomme.
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Oyama, T., Sfflbata, S., Matsumoto, F. et al. Adrenocortical function related to methoxyflurane anaesthesia and surgery in man. Canad. Anaes. Soc. J. 15, 362–368 (1968). https://doi.org/10.1007/BF03006961
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DOI: https://doi.org/10.1007/BF03006961