Abstract
Epidural administration of 3 rag of synthetic β-endorphin produced analgesia in 10 patients with intractable pain due to disseminated cancer. Mean onset of relief of pain was 24 ± 3 minutes and the mean duration of analgesia was 19 ± 3 hours. The onset of analgesia produced by the epidural injection of β-endorphin was slower and the duration less than those observed after intrathecal injection.
RéSUMé
L’administration dans l’espace épidural de β-endorphin synthétique à la dose de 3 ing a produit de l’analgésie chez 10 patients souffrant de douleur irréductible causée par le cancer. La période d’installation de l’analgésie a été de 24 ± 3 minutes et sa durée moyenne a été de 10 ± 3 heures.
L’analgésie produite par l’injection épidurale de β-endorphin s’est installée plus lentement et a été d’une durée plus courte que celle qu’on a déjà observée après l’injection intrathécale.
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Oyama, T., Fukushi, S. & Jin, T. Epidural β-endorphin in treatment of pain. Canad. Anaesth. Soc. J. 29, 24–26 (1982). https://doi.org/10.1007/BF03007943
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DOI: https://doi.org/10.1007/BF03007943