Abstract
Ten anaesthetized, heparinized healthy adult dogs were infused with protamine sulphate 3 mg.kg-1 and plasma ionized calcium was measured. A significant (p < 0.01) decrease in ionized calcium occurred which preceded the maximal reduction in cardiac output and systemic arterial pressure. The clinical implications of these results are discussed.
RéSUMé
On a mesuré le calcium plasmatique ionisé après l’administration de sulfate de protamine à la dose de 3 mg.kg-1 chez dix chiens normaux, héparinisés, sous anesthésie générale. On a observé une diminution significative (p < 0.01) du calcium ionisé. Cette diminution précédait la diminution maximale du débit cardiaque et de la pression artérielle que l’on a observée. Les implications cliniques de ces résultats sont discutées.
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Jones, R.M., Hill, A.B., Nahrwold, M.L. et al. Effect of protamine on plasma ionized calcium in the dog. Canad. Anaesth. Soc. J. 29, 65–67 (1982). https://doi.org/10.1007/BF03007951
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DOI: https://doi.org/10.1007/BF03007951