Abstract
The studies were performed on autopsy material of 18 patients who died between the ages of 70–89 y, and of 5 patients who died between 23–44 ys of age. White matter of the frontal lobe and of oerebellum was submitted for histological and biochemical analysis. The neuropathological data provided a rationale for dividing the material into two subgroups: one including patients mainly with vascular changes in the brain, and the other consisting of patients with senile atrophy of the Alzheimer type. Chemical alterations noted both in frontal lobe and in cerebellum were an increase in lysophosphatidylcholine content and a marked decrease in myelin yield. Additionally, The chemical results were almost identical in the two subgroups of patients, although they differ in neuropathological patterns of lesions. It is emphasized that the general decrease in myelin yield as well as some minor changes in myelin lipid pattern seem to be a sign of aging and are not connected with atrophy of the Alzheimer type.
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References
Bartlett G. (1959) Phosphorus Assays in Column Chromatography.J. Biol. Chem. 234, 466–468.
Berlet H. and Volk B. (1980) Studies of Human Myelin Proteins.Mech. Aging Dev. 14, 211–222.
Berlet H. and Volk B. (1980) Cerebral Myelin Lipids of Young and Old Human Adults.Biol. Chem. 366, 142.
England E. and Brun A. (1986) The White Matter Changes in Senile Dementia of Alzheimer Type: Neuropathological and Biochemical Correlates. X Intern. Congr. Neuropathol.Abstracts, Stockholm, 291.
Folch-Pi J., Lees M., and Sloane-Stanley G. (1957) A Simple Method for the Isolation and Purification of Total Lipides from Animal Tissues.J. Biol. Chem. 226, 497–511.
Horrocks L. (1967) Composition of Myelin from Peripheral and Central Nervous System of the Squirrel Monkey.J. Lipid Res. 8, 569–576.
Horrocks L. (1973) Composition and Metabolism of Myelin Phosphoglycerides during Maturation and Aging, in:Neurobiological Aspects of Maturation and Aging, pp. 383–395, Elsevier, Amsterdam.
Horrocks L. (1978) Pathway for Hydrolysis of Plasmalogens in Brain.Adv. Exp. Med. Biol. 101, 393–406.
Horrocks L., Sun G., and D’Amato R. (1979) Changes in Brain Lipids during Aging, in:Neurobiology of Aging (Ordy J. and K. Brizzee, eds.), pp. 359–367, Plenum, New York, London.
Horrocks L., Yeo Y., Harder H., Mozzi R., and Gorraci G. (1986) Choline Plasmalogens, Glycerophospholipid Methylation and Receptor-Mediated Activation of Adenylate Cyclase.Adv. Cyclic Nucleotide Protein Phosphorylation 20, 263–292.
Iwanowski L. (1984) Myelin in the Senile Rat Brain.Neuropath. Pol. 22, 219–223.
Iwanowski L. and Ostenda M. (1974) Ultrastructural Changes in the Brain Capillaries of Old Age. Material der 4. Jahrestagung der Gesellschaft für Neuropathologie der DDR. Mülhausen (Thür.), 121–122.
Mossakowski M., Dymecki J., and Wender M. (1981)Basic Neuropathology (Polish), PZWL, Warsaw.
Norton N. and Poduslo S. (1973) Myelination in Rat Brains: Method of Myelin Isolation.J. Neurochem. 21, 749–758.
Radin N., Lavin F., and Brown J. (1955) Determination of Cerebrosides.J. Biol. Chem. 217, 789–796.
Shingh H., Spritz M., and Geyer G. (1971) Studies of Brain Myelin in the “Quaking Mouse”.J. Lipid Res. 12, 473–483.
Sperry W. and Webb M. (1950) A Revision of the Schoenheimer-Sperry Method for Cholesterol Determination.J. Biol. Chem. 187, 97–106.
Stokes C. and Hawthorne J. (1987) Reduced Phosphoinositide Concentration in Anterior Temporal Cortex of Alzheimer Diseased Brains.48, 1018–1021.
Svennerholm L. (1964) The Distribution of Lipids in the Human Nervous System.J. Neurochem. 11, 839–859.
Wender M., Adamczewska-Goncerzewicz, Z. and Goncerzewicz A. (1979) Myelin Lipids in Wallerian Degeneration of the Rabbit Optic Nerve.Exp. Path. 17, 334–339.
Wender M., Adamczewska-Goncerzewicz Z., Stanislawska J., Pankrac J., Talkowska D., and Grochowalska A. (1987) Effect of Acute Hypoxia on Myelin Lipids.Neuropath. Pol. 25, 107–115.
Wender M., Adamczewska-Goncerzewicz Z., Talkowska D., and Pankrac J. (1988) Myelin Lipids in Senile Rat Brain.Neuropath. Pol., in press.
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Wender, M., Adamczewska-Goncerzewicz, Z., Szczech, J. et al. Myelin lipids in aging human brain. Neurochemical Pathology 8, 121–130 (1988). https://doi.org/10.1007/BF03160140
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DOI: https://doi.org/10.1007/BF03160140