Abstract
Spin-spin relaxation timeT 2 values of serum with and without iron were measured by magnetic resonance imaging (MRI) to find the proton relaxivity of Fe(III) in serum.T 2 values in serum containing definite amounts of added iron were also measured before and after addition of ascorbic acid. The difference in the 1/T 2 of serum with and without ascorbic acid was used for recalculation of the added iron values. Recalculated iron values confirm that the difference in healthy serum is caused by iron only. In addition, in order to find the paramagnetic contribution of serum iron,T 2 values of iron-deficient, healthy and iron-overloaded serum were measured before and after addition of ascorbic acid. The difference in the 1/T 2 values was then applied to the calculation of the serum iron values. The consistency of iron values determined from the difference to those by autoanalyzer suggests that the differences in diseased serum also represent the paramagnetic contribution of serum iron. The data imply that serum iron content in healthy, iron-deficient and iron-overloaded serum may be assessed by MRI.
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Yilmaz, A., Yurdakoc, M., Bernarding, J. et al. Paramagnetic contribution of serum iron to the spin-spin relaxation rate (1/T 2) measured by MRI. Appl Magn Reson 22, 11–22 (2002). https://doi.org/10.1007/BF03170519
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DOI: https://doi.org/10.1007/BF03170519