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Biological affinity and biodegradability of poly(propylene carbonate) prepared from copolymerization of carbon dioxide with propylene oxide

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Abstract

In this study we investigated bacterial and cell adhesion to poly(propylene carbonate) (PPC) films, that had been synthesized by the copolymerization of carbon dioxide (a global warming chemical) with propylene oxide. We also assessed the biocompatibility and biodegradability of the filmsin vivo, and their oxidative degradation in vitro. The bacteria adhered to the smooth, hydrophobic PPC surface after 4 h incubation.Pseudomonas aeruginosa andEnterococcus faecalis had the highest levels of adhesion,Escherichia coli andStaphylococcus aureus had the lowest levels, andStaphylococcus epidermidis was intermediate. In contrast, there was no adhesion of human cells (cell line HEp-2) to the PPC films, due to the hydrophobicity and dimensional instability of the surface. On the other hand, the PPC films exhibited good biocompatibility in the mouse subcutaneous environment. Moreover, contrary to expectation the PPC films degraded in the mouse subcutaneous environment. This is the first experimental confirmation that PPC can undergo surface erosion biodegradationin vivo. The observed biodegradability of PPC may have resulted from enzymatic hydrolysis and oxidative degradation processes. In contrast, the PPC films showed resistance to oxidative degradationin vitro. Overall, PPC revealed high affinity to bioorganisms and also good biodegradability.

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Authors and Affiliations

  1. Department of Chemistry, National Research Lab for Polymer Synthesis & Physics, Center for Integrated Molecular Systems, Polymer Research Institute, and BK School of Molecular Science, Pohang University of Science and Technology, 790-784, Pohang, Korea

    Gahee Kim & Moonhor Ree

  2. Department of Microbiology and Dongguk Medial Institute, Dongguk University College of Medicine, 780-714, Gyeongju, Korea

    Heesoo Kim & Ik Jung Kim

  3. Department of Pathology and Dongguk Medial Institute, Dongguk University College of Medicine, 780-714, Gyeongju, Korea

    Jung Ran Kim & Jong Im Lee

Authors
  1. Gahee Kim
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  2. Moonhor Ree
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  3. Heesoo Kim
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  4. Ik Jung Kim
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  5. Jung Ran Kim
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  6. Jong Im Lee
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Correspondence to Moonhor Ree or Heesoo Kim.

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Kim, G., Ree, M., Kim, H. et al. Biological affinity and biodegradability of poly(propylene carbonate) prepared from copolymerization of carbon dioxide with propylene oxide. Macromol. Res. 16, 473–480 (2008). https://doi.org/10.1007/BF03218547

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  • DOI: https://doi.org/10.1007/BF03218547

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