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Plasma immunoreactive thyrotropin releasing hormone (TRH) values in normal newborns

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Abstract

The study reported here extends investigation on the pituitary thyroid axis in newborn infants, including the assay of plasma immunoreactive TRH levels at different intervals after delivery. Blood samples were collected at birth and after 30, 60, 120 minutes, 6, 24 and 48 hours. Plasma TRH levels were also estimated in normal adult subjects and pregnant women. No significant difference was observed with regard to sex, pregnancy or age, except for a marked increase in newborn infants after delivery. Plasma TRH values, already moderately high at birth (mean 46 pg/mL., range 34–57) reached rapidly a peak of 78 pg/ml (range 60–93) 30 minutes after delivery, decreased rapidly between 30 minutes and 2 hours post-partum, then fell gradually to normal range at 24 hours. A comparison of plasma TRH and TSH levels measured simultaneously suggests that the acute TSH surge at delivery is mediated by TRH secretion.

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References

  1. Abuid J., Stinson D.A., Larsen P.R. Serum triiodothyronine and thyroxine in the neonate and the acute increases in these hormones following delivery. J. Clin. Invest. 52: 1195, 1973.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  2. Bassiri R.M., Utiger R.D. The preparation and specificity of antibody to thyrotropin releasing-hormone. Endocrinology 90: 722, 1972.

    Article  PubMed  CAS  Google Scholar 

  3. Chopra I.J., Chopra U., Smith S.R., Reza M., Solomon H. Reciprocal changes in serum concentrations of 3, 3′, 5′-triiodothyronine (reverse T3) and 3, 3′, 5-triiodothyronine (T3) in systemic illnesses. J. Clin. Endocrinol. Metab. 41: 1043, 1975.

    Article  PubMed  CAS  Google Scholar 

  4. Chopra I.J., Sack J., Fisher D.A. Circulating 3, 3′, 5′-triiodothyronine (reverse T3) in the human newborn. J. Clin. Invest. 55: 1137, 1975.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  5. Emerson C.H., Utiger R.D. Thyrotropin-releasing hormones in concentrated extract of rat plasma. Program 57th Annual Endocrine Society, 1975, Abstr. No. 200.

    Google Scholar 

  6. Eskay R.L., Oliver C., Ben-Jonathan N., Porter J.C.: Hypothalamic hormones in portal and systemic blood In: Motta M., Crosignani P.G., Martini L., Hypothalamic Hormones. Acad. Press, New York, 1975, p. 125.

    Google Scholar 

  7. Eskay R.L., Oliver C., Warberg J., Porter J.C. Inhibition of degradation and measurement of immunoreactive thyrotropin-releasing hormone in rat blood and plasma. Endocrinology 98: 269, 1976.

    Article  PubMed  CAS  Google Scholar 

  8. Fisher D.A., Odell W.D. Acute release of thyrotropin In the newborn. J. Clin. Invest. 48: 1670, 1969.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  9. Fisher D.A., Dussault J.H., Sack J., Chopra J. Ontogenesis of hypothalamic — pituitary — thyroid function and metabolism in man, sheep and rat. Recent. Progr. Horm. Res. 33: 59, 1977.

    Google Scholar 

  10. Grasso S., Filetti S., Mazzone D., Pezzino V., Vigneri R., Reitano G. Studio dell’asse ipofisi — tiroide in 5 neonati anencefali. Giornate Endocrinologiche Pisane, Pisa, 1977.

    Google Scholar 

  11. Greenwood F.C., Hunter W.M., Glover J.S. The preparation of 131 I-labelled human growth hormone of high specific radioactivity. Biochem. J. 89: 114, 1963.

    PubMed Central  PubMed  CAS  Google Scholar 

  12. Hefco E., Krulich L., Illner P., Larsen P.R. Effect of acute exposure to cold on the activity of the hypothalamic-pituitary-thyroid system. Endocrinology 97: 1185, 1975.

    Article  PubMed  CAS  Google Scholar 

  13. Jackson I.M.D., Reichlin S. Thyrotropin-releasing hormone (TRH): distribution in the brain, blood and urine of the rat. Life Sci. 14: 2259, 1974.

    Article  PubMed  CAS  Google Scholar 

  14. Montoya E., Seibel M.J., Wilber J.F. Thyrotropin-releasing hormones secretory physiology: studies by radioimmunoassay and affinity chromatography. Endocrinology 96: 1413, 1975.

    Article  PubMed  CAS  Google Scholar 

  15. Oliver C., Charvet J.P., Codaccioni J.L., Vague J. Radioimmunoassay of thyrotropin-releasing hormone (TRH) in human plasma and urine. J. Clin. Endocrlinol. Metab. 39: 406, 1974.

    Article  CAS  Google Scholar 

  16. Oliver C., Charvet J.P., Codaccioni J.L., Vague J. TRH levels in human cerebrospinal fluid, plasma and urine. Endocrinol. Exp. (Bratisl.) 8: 158, 1974.

    Google Scholar 

  17. Oliver C., Eskay R.L., Ben-Jonathan N., Porter J.C. Distribution and concentration of TRH in the rat brain. Endocrinology 95: 540, 1974.

    Article  PubMed  CAS  Google Scholar 

  18. Oliver C., Taurog A., Porter J.C. Physiologie de la secretion de la TRH. Nouv. Presse Med. 3: 1941, 1974.

    PubMed  CAS  Google Scholar 

  19. Oliver C., Lombardi G., Minozzi M., Usategui Echeverria R., Rozemberg J., Vaudry H., Mourre M. Thyrotropin-releasing hormone (TRH) radioimmunoassay and its application. Il Simposio Intern. « Applicazioni delle teeniche radioisotopiche in vitro », Capri, 1975.

    Google Scholar 

  20. Utiger R.D., Bassiri R.M. Thyrotropin releasing hormone (TRH) radioimmunoassay. In: Gual C., Rosemberg E.. Hypothalamic hypo-physiotropic hormones. Excerpta Medica, Amsterdam, 1973, p. 146.

    Google Scholar 

  21. Vagenakis A.G., Roti E., Mannix J., Braverman L.E. Problems in the measurement of urinary TRH. J. Clin. Endocrinol. Metab. 41: 801, 1975.

    Article  PubMed  CAS  Google Scholar 

  22. Vaitukaitis J., Robbins J.B., Nieschlag E., Ross G.T. A method for producing specific antisera with small doses of immunogen. J. Clin. Endocrinol. Metab. 33: 988, 1971.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Endocrinology, II School of Medicine, University of Naples, Italy

    G. Lombardi, G. Lupoli, F. Scopacasa, R. Panza & M. Minozzi

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  1. G. Lombardi
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  2. G. Lupoli
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  3. F. Scopacasa
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  4. R. Panza
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  5. M. Minozzi
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Lombardi, G., Lupoli, G., Scopacasa, F. et al. Plasma immunoreactive thyrotropin releasing hormone (TRH) values in normal newborns. J Endocrinol Invest 1, 69–72 (1978). https://doi.org/10.1007/BF03346773

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  • DOI: https://doi.org/10.1007/BF03346773

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