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Estrogenic treatment does not modify the TSH and PRL responses to domperidone and TRH in patients with tumoral hyperprolactinemia

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Abstract

To verify if the low estrogen regimen could condition the TSH hyperresponsivity and PRL hyporesponsivity to antidopaminergic drugs seen by us and others in patients bearing prolactinoma, the effect of ethynilestradiol treatment (50 μg/day/14 days) on TSH and PRL responses to domperidone in 6 women with tumoral hyperprolactinemia and hypoestrogenemia were studied. Estrogenic treatment was unable to modify the TSH and PRL responsiveness either to domperidone and TRH. These data do not support the hypothesis that hypoestrogenemia could cause the peculiar TSH and PRL pattern in response to antidopaminergic drugs, in patients bearing prolactinoma. Also the TRH releasable pool of TSH and PRL in these patients seems to be unaffected by estrogenic treatment.

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Authors and Affiliations

  1. Cattedre di Endocrinologia e di Malattie del Ricambio dell’Università di Torino, Ospedale Molinette; C.so Polonia, 14, 10126, Torino, Italy

    E. Ghigo, G. Pogliano, A. Bertagna, F. Camanni & F. Massara

  2. Ospedale Ostetrico e Ginecologico S. Anna, 10100, Torino, Italy

    C. Campagnoli

Authors
  1. E. Ghigo
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  2. G. Pogliano
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  3. C. Campagnoli
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  4. A. Bertagna
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  5. F. Camanni
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  6. F. Massara
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Supported in part by a grant from Ministero Pubblica Istruzione, Rome, Italy.

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Ghigo, E., Pogliano, G., Campagnoli, C. et al. Estrogenic treatment does not modify the TSH and PRL responses to domperidone and TRH in patients with tumoral hyperprolactinemia. J Endocrinol Invest 7, 525–527 (1984). https://doi.org/10.1007/BF03348462

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  • DOI: https://doi.org/10.1007/BF03348462

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