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Complementary DNA Encoding nm23/NDP Kinase Gene from the Korean Tiger Shark Scyliorhinus torazame

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Abstract:

A new tumor suppressor gene, snm23, homologous to the gene for human nucleoside diphosphate kinase nm23/NDP was first cloned from Korean tiger shark (Scyliorhinus torazame) skin λ ZAP-II complementary DNA library. The gene (named snm23) containing the tumor metastasis suppressor protein was sequenced. The nucleotide and deduced amino acid sequences of snm23 revealed an open reading frame of 450 bp that corresponded to a protein of 150 amino acid residues, with a calculated molecular mass of 16.8 kDa. Sequence comparison of snm23 with nm23/NDP kinases was performed. In order to determine tissue specificity, reverse transcription–polymerase chain reaction was used. The expression of snm23/NDP kinase was detected in tissues from skin, cartilage, and liver of Korean tiger shark.

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Authors and Affiliations

  1. Department of Microbiology, Pukyong National University, Pusan 608-737, Korea, , , , , , KR

    Jung Jong Cho, Jae Hyung Lee, Tae-Jin Choi & Young Tae Kim

  2. Department of Chemistry, Pukyong National University, Pusan 608-737, Korea, , , , , , KR

    Se-Kwon Kim

Authors
  1. Jung Jong Cho
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  2. Jae Hyung Lee
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  3. Se-Kwon Kim
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  4. Tae-Jin Choi
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  5. Young Tae Kim
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Received April 1, 1998; accepted September 30, 1998.

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Cho, J., Lee, J., Kim, SK. et al. Complementary DNA Encoding nm23/NDP Kinase Gene from the Korean Tiger Shark Scyliorhinus torazame . Mar. Biotechnol. 1, 131–136 (1999). https://doi.org/10.1007/PL00011760

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  • DOI: https://doi.org/10.1007/PL00011760

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