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Calprotectin (S100A8/S100A9): a key protein between inflammation and cancer

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Abstract

Background

Calprotectin (S100A8/S100A9), a heterodimeric EF-hand Ca2+ binding protein, are abundant in cytosol of neutrophils and are involved in inflammatory processes and several cancerous pathogens.

Objective

The purpose of the present systematic review is to evaluate the pro- and anti-tumorigenic functions of calprotectin and its relation to inflammation.

Materials and methods

We conducted a review of studies published in the Medline (1966–2018), Scopus (2004–2018), ClinicalTrials.gov (2008–2018) and Google Scholar (2004–2018) databases, combined with studies found in the reference lists of the included studies.

Results

Elevated levels of S100A8/S100A9 were detected in inflammation, neoplastic tumor cells and various human cancers. Recent data have explained that many cancers arise from sites of infection, chronic irritation, and inflammation. The inflammatory microenvironment which largely includes calprotectin, has an essential role on high producing of inflammatory factors and then on neoplastic process and metastasis.

Conclusion

Scientists have shown different outcomes in inflammation, malignancy and apoptosis whether the source of the aforementioned protein is extracellular or intracellular. These findings are offering new insights that anti-inflammatory therapeutic agents and anti-tumorigenic functions of calprotectin can lead to control cancer development.

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Acknowledgements

This work was supported by the Deputy of Research and Technology, Qazvin University of Medical Sciences., Qazvin, Iran.

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Authors and Affiliations

  1. Department of Biochemistry, University of Tabriz, Tabriz, Iran

    Fatemeh Shabani & Majid Mahdavi

  2. Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran

    Alireza Farasat & Nematollah Gheibi

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  1. Fatemeh Shabani
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  2. Alireza Farasat
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  3. Majid Mahdavi
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  4. Nematollah Gheibi
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All authors contributed equally in this work.

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Correspondence to Nematollah Gheibi.

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Shabani, F., Farasat, A., Mahdavi, M. et al. Calprotectin (S100A8/S100A9): a key protein between inflammation and cancer. Inflamm. Res. 67, 801–812 (2018). https://doi.org/10.1007/s00011-018-1173-4

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