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Mechanisms of heat shock response in mammals

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Abstract

Heat shock (HS) is one of the best-studied exogenous cellular stresses. The cellular response to HS utilizes ancient molecular networks that are based primarily on the action of stress-induced heat shock proteins and HS factors. However, in one way or another, all cellular compartments and metabolic processes are involved in such a response. In this review, we aimed to summarize the experimental data concerning all aspects of the HS response in mammalian cells, such as HS-induced structural and functional alterations of cell membranes, the cytoskeleton and cellular organelles; the associated pathways that result in different modes of cell death and cell cycle arrest; and the effects of HS on transcription, splicing, translation, DNA repair, and replication.

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Acknowledgments

This work was supported in part by grants from the Ministry of Science and Education of the Russian Federation (8126, 8052), grants from the Russian Foundation for Basic Research (12-04-33040, 13-04-00604), and a grant from the Presidium of the Russian Academy of Sciences (MCB grant).

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  1. Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology, Russian Academy of Sciences, 119334, Moscow, Russia

    Artem K. Velichko, Elena N. Markova, Nadezhda V. Petrova, Sergey V. Razin & Omar L. Kantidze

  2. Department of Molecular Biology, Lomonosov Moscow State University, 119991, Moscow, Russia

    Nadezhda V. Petrova & Sergey V. Razin

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  1. Artem K. Velichko
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  2. Elena N. Markova
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  3. Nadezhda V. Petrova
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  5. Omar L. Kantidze
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Correspondence to Omar L. Kantidze.

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Velichko, A.K., Markova, E.N., Petrova, N.V. et al. Mechanisms of heat shock response in mammals. Cell. Mol. Life Sci. 70, 4229–4241 (2013). https://doi.org/10.1007/s00018-013-1348-7

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